The fight will take place in San Antonio, Texas, with the contract weight set at 130 pounds, crucially this will present a challenge for the American, who missed weight against Francisco Fonseca.
Will âTankâ be able to finally showcase his full potential after leaving his hometown of Baltimore to Las Vegas to work closely with his trainer Calvin Ford alongside mentor and promoter Floyd Mayweather Jr?
With Teofimo Lopez, Vasiliy Lomachenko, Devin Haney, Ryan Garcia, Luke Campbell and many more in the mix in and around both fightersâ weight, the winner should have many options ahead.
Hereâs everything you need to know about the fight at the Alamodome in Texas.
When and where is the fight?
The fight will take place at the Alamodome in San Antonio, Texas on 31 October. You can expect the ring walks to take place some time after 3am UK time on Sunday morning.
What TV channel is it on and is there a live stream?
American fans will be able to catch the fight on Showtime Sports in a pay-per-view event.
The fight will cost fans $74.99 in the United States.
The fight will air on Channel 5 in the UK, meaning British fight fans will get it for free, coverage beginning at 2am on Sunday.
A live stream of the fight in the UK is available on My5 here.
Santa Cruz: 4/1
Davis by KO/TKO: 11/10
Davis on points: 5/4
Santa Cruz by KO/TKO: 12/1
Santa Cruz on points: 5/1
Over or Under 10.5 rounds: 5/6