| | OLB | Signed (The Buffalo Bills signed OLB Dawuane Smoot.) |
| | WR | Signed (The Buffalo Bills signed WR Chase Claypool.) |
| | LB | Signed (The Buffalo Bills signed LB Deion Jones.) From |
| | CB | Signed (The Buffalo Bills signed CB Keni-H Lovely.) |
| | OL | Signed (The Buffalo Bills signed OL Gunner Britton.) |
| | QB | Signed (The Buffalo Bills signed QB Gunnar Watson.) |
| | DB | Signed (The Buffalo Bills signed S Alfahiym Walcott.) |
| | WR | Signed (The Buffalo Bills signed WR Xavier Johnson Jr.) |
| | RB | Signed (The Buffalo Bills signed RB Frank Gore Jr.) |
| | WR | Signed (The Buffalo Bills signed WR Lawrence Keys III.) |
| | OL | Signed (The Buffalo Bills signed OG Keaton Bills.) |
| | CB | Signed (The Buffalo Bills signed CB Sheridan Jones.) |
| | WR | Signed (The Buffalo Bills signed WR Quintez Cephus.) |
| | DL | Signed (The Buffalo Bills signed IDL Branson Deen.) |
| | K/P | Signed (The Buffalo Bills signed P Jack Browning.) |
| | DT | Signed (The New England Giants signed DT Jordan Phillips.) To |
| | T | Signed (The Buffalo Bills signed OT La'el Collins.) |
| | WR | Traded (The Buffalo Bills traded WR Stefon Diggs to the Houston Texans.) To |
| | DT | Signed (The Buffalo Bills signed DT DeShawn Williams.) From |
| | QB | Declared Free Agent (QB Kyle Allen elected free agency.) |
| | RB | Retired (Buffalo Bills RB Damien Harris retired from the NFL.) |
| | DT | Signed (The Buffalo Bills signed DL Austin Johnson.) |
| | OL | Signed (The Buffalo Bills signed OL Will Clapp.) |
| | S | Signed (The Buffalo Bills signed S Mike Edwards.) From |
| | DE | Signed (The Buffalo Bills signed DE Casey Toohill.) |
| | LB | Declared Free Agent (LB Tyrel Dodson elected free agency.) |
| | WR | Declared Free Agent (WR Trent Sherfield elected free agency.) |
| | DT | Declared Free Agent (DT Tim Settle elected free agency.) |
| | WR | Signed (The Buffalo Bills signed WR Curtis Samuel.) |
| | DT | Declared Free Agent (Buffalo Bills DT Poona Ford declared free agency.) |
| | CB | Declared Free Agent (Buffalo Bills CB Dane Jackson declared free agency.) |
| | LB | Signed (The Buffalo Bills signed LB Nicholas Morrow.) |
| | WR | Signed (The Buffalo Bills signed WR Mack Hollins.) |
| | DL | Declared Free Agent (DE Leonard Floyd elected free agency.) |
| | WR | Declared Free Agent (WR Gabe Davis elected free agency.) |
| | DB | Released (The Buffalo Bills released CB Tre'Davious White.) |
| | S | Released (The Buffalo Bills released SAF Jordan Poyer.) |
| | QB | Signed (The Buffalo Bills signed QB Mitch Trubisky.) |
| | P | Re-signed (The Buffalo Bills re-signed P Matt Haack.) |
| | RB | Released (The Buffalo Bills released RB Nyheim Hines.) |
| | CB | Released (The Buffalo Bills released CB Siran Neal.) |
| | WR | Released (The Buffalo Bills released WR Deonte Harty.) |
| | C | Released (The Buffalo Bills released C Mitch Morse.) |
| | OL | Traded (The Buffalo Bills traded OL Ryan Bates to the Chicago Bears.) To |
| | DL | Contract Expired (DL Andrew Brown's contract expired with the Buffalo Bills.) |
| | CB | Contract Expired (CB Josh Norman's contract expired with the Buffalo Bills.) |
| | OL | Contract Expired (DL Greg Mancz's contract expired with the Buffalo Bills.) |
| | G | Contract Expired (G Germain Ifedi's contract expired with the Buffalo Bills.) |
| | LB | Contract Expired (LB A.J. Klein's contract expired with the Buffalo Bills.) |
| | DT | Signed (The Buffalo Bills signed DT Eli Ankou to a reserve/future contract.) |
| | QB | Signed (The Buffalo Bills signed QB Shane Buechele to a reserve/future contract.) |
| | RB | Signed (The Buffalo Bills signed RB Darrynton Evans to a reserve/future contract.) From |
| | OL | Signed (The Buffalo Bills signed OL Kevin Jarvis to a reserve/future contract.) |
| | DE | Signed (The Buffalo Bills signed DE Kameron Cline to a reserve/future contract.) |
| | T | Signed (The Buffalo Bills signed T Richard Gouraige to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Bryan Thompson to a reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Kyron Brown to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Andy Isabella to a reserve/future contract.) |
| | WR | Signed (The Buffalo Bills signed WR Tyrell Shavers to a reserve/future contract.) |
| | DB | Signed (The Buffalo Bills signed DB Kendall Williamson to a reserve/future contract from the Chicago Bears practice squad.) From |
| | TE | Signed (The Buffalo Bills signed TE Tre' McKitty to reserve/future contract.) |
| | CB | Signed (The Buffalo Bills signed CB Ja'Marcus Ingram to a reserve/future contract.) |
| | LB | Activated (The Buffalo Bills elevated LB A.J. Klein from the practice squad.) |
| | P | Released (The Buffalo Bills released P Matt Haack.) |
| | DT | Pract. squad add (The Buffalo Bills signed DT Eli Ankou to the practice squad.) |
| | WR | Signed (The Buffalo Bills signed WR KJ Hamler to a reserve/futures deal.) From |
| | WR | Activated (The Buffalo Bills elevated WR Andy Isabella from the practice squad.) |
| | P | Pract. squad add (The Buffalo Bills signed P Matt Haack to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR Andy Isabella to the practice squad.) |
| | RB | Released (The Buffalo Bill have released RB Leonard Fournette.) |
| | LB | Pract. squad add (The Buffalo Bills assigned LB A.J. Klein to the practice squad.) |
| | LB | Activated (The Buffalo Bills signed LB A.J. Klein to the active roster.) |
| | WR | Activated (The Buffalo Bills signed WR Andy Isabella to the active roster.) |
| | DT | Released (The Buffalo Bills released DL Eli Ankou.) |
| | LB | Pract. squad add (The Buffalo Bills signed LB A.J. Klein to the practice squad.) |
| | RB | Pract. squad add (The Buffalo Bills assigned RB Leonard Fournette to the practice squad.) |
| | RB | Activated (The Buffalo Bills elevated RB Leonard Fournette from the practice squad.) |
| | G | Pract. squad add (The Buffalo Bills signed G Germain Ifedi to the practice squad.) |
| | CB | Released (The Buffalo Bills released CB Tre Norwood.) |
| | DT | Activated (The Buffalo Bills activated DT DaQuan Jones from the IRD.) |
| | CB | Released (The Buffalo Bills released DB Herb Miller.) |
| | DE | Pract. squad add (The Buffalo Bills assigned DL Kameron Cline to the practice squad.) |
| | G | Waived (The Buffalo Bills waived G Germain Ifedi.) |
| | CB | Activated (The Buffalo Bills activated DB Kaiir Elam.) |
| | RB | Activated (The Buffalo Bills elevated RB Leonard Fournette to the active roster from the practice squad.) |
| | DT | Placed on Injured Reserve (The Buffalo Bills placed DL Jordan Phillips on IR.) |
| | DT | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed DL DaQuan Jones on IRD.) |
| | WR | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed WR Justin Shorter on IRD.) |
| | LB | Released (The Buffalo Bills released LB A.J. Klein.) |
| | TE | Activated (The Buffalo Bills activated TE Dawson Knox from injured reserve.) |
| | TE | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed TE Dawson Knox on the IRD.) |
| | CB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed CB Kaiir Elam on the IRD.) |
| | WR | Activated (The Buffalo Bills elevated WR Andy Isabella to the active roster.) |
| | CB | Activated (The Buffalo Bills elevated CB Ja'Marcus Ingram to the active roster.) |
| | CB | Activated (The Buffalo Bills elevated CB Josh Norman to the active roster.) |
| | DE | Placed on Injured Reserve (The Buffalo Bills placed DE Kameron Cline on practice squad injured reserve.) |
| | CB | Pract. squad add (The Buffalo Bills signed SAF Tre Norwood to the practice squad.) |
| | TE | Pract. squad add (The Buffalo Bills signed TE Tre' McKitty to the practice squad.) |
| | TE | Released (The Buffalo Bills released TE Joel Wilson.) |
| | CB | Activated (The Buffalo Bills elevated CB Josh Norman to the active roster.) |
| | CB | Placed on Injured Reserve (The Buffalo Bills placed DB Kaiir Elam on IR.) |
| | DT | Signed (The Buffalo Bills signed DL Linval Joseph.) |
| | CB | Traded (The Green Bay Packers traded CB Rasul Douglas to the Buffalo Bills.) From |
| | DL | Released (The Buffalo Bills released DL Kendal Vickers.) |
| | RB | Pract. squad add (The Buffalo Bills signed RB Leonard Fournette to the practice squad.) |
| | WR | Activated (The Buffalo Bills elevated WR Andy Isabella to the active squad.) |
| | CB | Activated (The Buffalo Bills elevated CB Josh Norman to the active squad.) |
| | TE | Placed on Injured Reserve (The Buffalo Bills placed TE Dawson Knox on the IR.) |
| | DT | Signed (The Buffalo Bills signed DT Eli Ankou to the practice squad.) |
| | DL | Pract. squad add (The Buffalo Bills assigned DL Kendal Vickers to the practice squad.) |
| | DL | Activated (The Buffalo Bills elevated DT Kendal Vickers to the active squad.) |
| | RB | Placed on Injured Reserve (The Buffalo Bills have placed RB Damien Harris on injured reserve.) |
| | RB | Activated (The Buffalo Bills have activated RB Ty Johnson.) |
| | CB | Pract. squad add (The Buffalo Bills assigned DB Ja'Marcus Ingram to the practice squad.) |
| | CB | Activated (The Buffalo Bills elevated CB Ja'Marcus Ingram to the active squad.) |
| | LB | Activated (The Buffalo Bills activated LB Baylon Spector from the IRD.) |
| | DL | Pract. squad add (The Buffalo Bills signed DL Andrew Brown to the practice squad.) |
| | LB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed LB Baylon Spector on IRD.) |
| | LB | Activated (The Buffalo Bills signed LB A.J. Klein to the active roster.) |
| | DT | Placed on Injured Reserve (The Buffalo BIlls placed DL DaQuan Jones on IR.) |
| | LB | Placed on Injured Reserve (The Buffalo BIlls placed LB Matt Milano on IR.) |
| | CB | Pract. squad add (The Buffalo Bills signed CB Josh Norman to the practice squad. ) |
| | DL | Pract. squad add (The Buffalo Bills assigned DL Kendal Vickers to the practice squad.) |
| | CB | Pract. squad add (The Buffalo Bills assigned DB Ja'Marcus Ingram to the practice squad.) |
| | CB | Activated (The Buffalo Bills activated CB Ja'Marcus Ingram from the practice squad.) |
| | DB | Placed on Injured Reserve (The Buffalo Bills placed CB Tre'Davious White on injured reserve.) |
| | LB | Activated (The Buffalo Bills activated LB Von Miller from injured reserve.) |
| | DL | Activated (The Buffalo Bills activated DT Kendal Vickers from the practice squad.) |
| | LB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills designated LB Von Miller from the PUP list.) |
| | DT | Signed (The Atlanta Falcons signed DT Eli Ankou from the Buffalo Bills practice squad.) To |
| | WR | Released (The Buffalo Bills released WR Marcell Ateman.) |
| | CB | Pract. squad add (The Buffalo Bills signed CB Herb Miller to the practice squad.) |
| | LB | Retired (LB Christian Kirksey retired from the NFL.) |
| | LB | Pract. squad add (The Buffalo Bills signed LB A.J. Klein to the practice squad.) |
| | QB | Waived Injury (The Buffalo Bills waived QB Matt Barkley due to injury.) |
| | LB | Signed (The Buffalo Bills signed LB Christian Kirksey to the practice squad.) |
| | QB | Signed (The Buffalo Bills signed QB Shane Buechele to the practice squad.) |
| | CB | Pract. squad add (The Buffalo Bills signed CB Ja'Marcus Ingram to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Marcell Ateman to the practice squad.) |
| | TE | Pract. squad add (The Buffalo Bills assigned TE Joel Wilson to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR Andy Isabella to the practice squad.) |
| | LB | Placed on Injured Reserve (The Buffalo Bills placed LB Baylon Spector on IR.) |
| | OL | Pract. squad add (The Buffalo Bills signed OL Greg Mancz to the practice squad.) |
| | DL | Pract. squad add (The Buffalo Bills signed DT Kendall Vickers to the practice squad.) |
| | G | Signed (The Buffalo Bills signed OL Germain Ifedi.) |
| | OL | Pract. squad add (The Buffalo Bills signed OL Kevin Jarvis to the practice squad.) |
| | LS | Re-signed (The Buffalo Bills re-signed LS Reid Ferguson.) |
| | WR | Placed on Injured Reserve (The Buffalo Bills placed WR Justin Shorter on IR.) |
| | DE | Pract. squad add (The Buffalo Bills signed DE Kameron Cline to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Tyrell Shavers to the practice squad.) |
| | CB | Pract. squad add (The Buffalo Bills signed CB Kyron Brown to the practice squad.) |
| | T | Pract. squad add (The Buffalo Bills signed T Richard Gouraige to the practice squad.) |
| | RB | Pract. squad add (The Buffalo Bills signed RB Ty Johnson to the practice squad.) |
| | DT | Pract. squad add (The Buffalo Bills signed DT Eli Ankou to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Bryan Thompson to the practice squad.) |
| | CB | Released (The Buffalo Bills released CB Ja'Marcus Ingram.) |
| | T | Released (The Buffalo Bills released OL David Quessenberry.) |
| | OLB | Traded (The Buffalo Bills traded DL Boogie Basham to the New York Giants.) To |
| | OL | Released (The Buffalo Bills released OL Greg Mancz.) |
| | WR | Released (The Buffalo Bills released WR Bryan Thompson.) |
| | WR | Released (The Buffalo Bills released WR Marcell Ateman.) |
| | LB | Released (The Buffalo Bills released LB Travin Howard.) |
| | LS | Released (The Buffalo Bills released LS Reid Ferguson.) |
| | G | Released (The Buffalo Bills released OL Nick Broeker.) |
| | QB | Placed on Injured Reserve (The Buffalo Bills placed QB Matt Barkley on injured reserve.) |
| | WR | Released (The Buffalo Bills released WR Tyrell Shavers.) |
| | DT | Released (The Buffalo Bills released DT DJ Dale.) |
| | G | Released (The Buffalo Bills released OL Ike Boettger.) |
| | DL | Released (The Buffalo Bills released DT Kendal Vickers.) |
| | RB | Released (The Buffalo Bills released RB Jordan Mims.) |
| | DE | Released (The Buffalo Bills released DE Kameron Cline.) |
| | S | Released (The Buffalo Bills released DB Zayne Anderson.) |
| | LB | Released (The Buffalo Bills released LB A.J. Klein.) |
| | TE | Waived (The Buffalo Bills waived TE Joel Wilson.) |
| | T | Waived (The Buffalo Bills waived OL Richard Gouraige.) |
| | RB | Released (The Buffalo Bills released RB Ty Johnson.) |
| | DT | Released (The Buffalo Bills released DL Eli Ankou.) |
| | WR | Released (The Buffalo Bills released WR KeeSean Johnson.) |
| | CB | Released (The Buffalo Bills released DB Alex Austin.) |
| | WR | Waived (The Buffalo Bills waived WR Andy Isabella.) |
| | OL | Released (The Buffalo Bills released OL Kevin Jarvis.) |
| | CB | Released (The Buffalo Bills released DB Kyron Brown.) |
| | RB | Released (The Buffalo Bills released RB Darrynton Evans.) |
| | FS | Released (The Buffalo Bills released DB Dean Marlowe.) |
| | LB | Released (The Buffalo Bills released LB DaShaun White.) |
| | WR | Released (The Buffalo Bills released WR Dezmon Patmon.) |
| | TE | Released (The Buffalo Bills released TE Jace Sternberger.) |
| | S | Released (The Buffalo Bills released DB Jared Mayden.) |
| | WR | Waived (The Buffalo Bills waived WR Isaiah Coulter.) |
| | OL | Released (The Buffalo Bills released OL Garrett McGhin.) |
| | DT | Released (The Buffalo Bills released DL Cortez Broughton.) |
| | LB | Waived Injury (The Buffalo Bills waived LB Shane Ray due to injury.) |
| | LB | Signed (The Buffalo Bills signed LB DaShaun White.) |
| | RB | Signed (The Buffalo Bills signed RB Ty Johnson.) |
| | LB | Placed on Injured Reserve (The Buffalo Bills placed LB Shane Ray on injured reserve. . ) |
| | OL | Signed (The Buffalo Bills signed OL Garrett McGhin.) |
| | T | Placed on Injured Reserve (The Buffalo Bills placed OL Tommy Doyle on IR.) |
| | LB | Activated (The Buffalo Bills activated LB Tyler Matakevich.) |
| | T | Retired (OL Brandon Shell retired from the NFL.) |
| | DT | Activated (The Buffalo Bills activated DL Jordan Phillips.) |
| | CB | Placed on Injured Reserve (The Buffalo Bills placed CB Cameron Dantzler on the IR after being waived.) |
| | WR | Signed (The Buffalo Bills signed WR Andy Isabella.) |
| | CB | Signed (The Buffalo Bills signed CB Kyron Brown.) |
| | WR | Released (The Buffalo Bill released WR Jalen Wayne.) |
| | CB | Waived (The Buffalo Bills waived CB Cam Dantzler.) |
| | LB | Placed on PUPL (The Buffalo Bills place LB Tyler Matakevich on the physically unable to perform list.) |
| | RB | Reserve/non football injury (The Buffalo Bills placed RB Nyheim Hines on the non-football injury list.) |
| | LB | Placed on PUPL (The Buffalo Bills placed LB Von Miller on the physically unable to perform list.) |
| | DT | Placed on PUPL (The Buffalo Bills placed DT Jordan Phillips on the physically unable to perform list.) |
| | TE | Waived (The Buffalo Bills placed TE Nick Guggemos on waivers.) |
| | RB | Signed (The Buffalo Bills signed RB Darrynton Evans. ) |
| | TE | Signed (The Buffalo Bills signed TE Jace Sternberger. ) |
| | OL | Waived (The Buffalo Bills waived OL Noah Henderson.) |
| | TE | Signed (The Buffalo Bills signed TE Nick Guggemos.) |
| | TE | Placed on Injured Reserve (The Buffalo Bills placed TE Zach Davidson on IR.) |
| | CB | Signed (The Buffalo Bills signed CB Cameron Dantzler Sr.) |
| | CB | Released (The Buffalo Bills released CB Kyler McMichael.) |
| | RB | Waived (The Buffalo Bills waived RB Isaiah Bowser.) |
| | DL | Signed (The Buffalo Bills signed DE Leonard Floyd.) |
| | DT | Released (The Buffalo Bills released DT Brandin Bryant.) |
| | WR | Signed (The Buffalo Bills signed WR Marcell Ateman.) |
| | WR | Released (The Buffalo Bills released WR Braydon Johnson.) |
| | T | Signed (The Buffalo Bills signed OL Brandon Shell.) |
| | TE | Signed (The Buffalo Bills signed TE Joel Wilson.) From |
| | FS | Signed (The Buffalo Bills signed S Dean Marlowe.) |
| | RB | Signed (The Buffalo Bills signed RB Isaiah Bowser.) |
| | LB | Signed (The Buffalo Bills signed LB Shane Ray.) |
| | LB | Signed (The Buffalo Bills signed LB Travin Howard. ) |
| | DT | Signed (The Buffalo Bill signed DT DJ Dale.) |
| | WR | Signed (The Buffalo Bills signed WR Isaiah Coulter.) |
| | RB | Signed (The Buffalo Bills signed WR Jordan Mims.) |
| | WR | Signed (The Buffalo Bills signed WR Tyrell Shavers.) |
| | T | Signed (The Buffalo Bills signed OL Richard Gouraige.) |
| | WR | Signed (The Buffalo Bills signed WR Jalen Wayne.) |
| | OL | Signed (The Buffalo Bills signed OL Noah Henderson.) |
| | DE | Claimed (The Buffalo Bills claimed DE Kameron Cline off waivers.) |
| | DT | Signed (The Buffalo Bills signed DL Poona Ford.) |
| | RB | Signed (The Buffalo Bills signed RB Latavius Murray.) |
| | LB | Re-signed (The Buffalo Bills re-signed LB A.J. Klein.) |
| | OL | Signed (The Buffalo Bills signed OG Kevin Jarvis.) |
| | DE | Re-signed (The Buffalo Bills re-signed DL Shaq Lawson.) |
| | DT | Re-signed (The Buffalo Bills re-signed DL Jordan Phillips.) |
| | S | Signed (The Buffalo Bills signed DB Taylor Rapp.) |
| | G | Signed (The Buffalo Bills signed OL David Edwards.) |
| | T | Re-signed (The Buffalo Bills re-signed OL David Quessenberry.) |
| | RB | Signed (The Buffalo Bills signed RB Damien Harris.) |
| | WR | Signed (The Buffalo Bills signed WR Trent Sherfield.) |
| | WR | Released (The Buffalo Bills released WR Isaiah McKenzie.) |
| | S | Re-signed (The Buffalo Bills re-signed DB Jordan Poyer.) |
| | QB | Signed (The Buffalo Bills signed QB Kyle Allen.) |
| | WR | Signed (The Buffalo Bills signed WR Deonte Harty.) |
| | G | Signed (The Buffalo Bills signed OL Connor McGovern.) |
| | TE | Declared Free Agent (TE Tommy Sweeney declared free agency.) |
| | LB | Declared Free Agent (LB Tremaine Edmunds declared free agency.) |
| | G | Declared Free Agent (OG Connor McGovern declared free agency.) |
| | T | Declared Free Agent (OL David Quessenberry declared free agency.) |
| | DT | Declared Free Agent (DT Jordan Phillips declared free agency.) |
| | G | Declared Free Agent (OG Greg Van Roten declared free agency.) |
| | WR | Declared Free Agent (WR Jamison Crowder declared free agency.) |
| | OL | Declared Free Agent (OG Rodger Saffold declared free agency.) |
| | S | Declared Free Agent (S Jaquan Johnson declared free agency.) |
| | RB | Declared Free Agent (RB Devin Singletary declared free agency.) |
| | QB | Declared Free Agent (QB Case Keenum declared free agency.) |
| | RB | Declared Free Agent (RB Taiwan Jones declared free agency.) |
| | FS | Declared Free Agent (FS Dean Marlowe declared free agency.) |
| | WR | Declared Free Agent (WR Jake Kumerow declared free agency.) |
| | S | Declared Free Agent (S Jordan Poyer declared free agency.) |
| | LB | Declared Free Agent (LB A.J. Klein declared free agency.) |
| | OL | Declared Free Agent (OL Bobby Hart declared free agency.) |
| | DE | Declared Free Agent (DE Shaq Lawson declared free agency.) |
| | S | Signed (The Buffalo Bills signed SAF Zayne Anderson from the Kansas City Chiefs' practice squad.) From |