| Player | Date | Status | Injury |
|---|---|---|---|
| Justise Hairston | Sep 8, 2009 | Injured Reserve | Knee |
| Jermaine McGhee | Sep 8, 2009 | Injured Reserve | Undisclosed |
| Marvin Philip | Sep 8, 2009 | Injured Reserve | Undisclosed |
| Derek Schouman | Sep 22, 2009 | Injured Reserve | Right knee |
| Brad Butler | Sep 22, 2009 | Injured Reserve | Right knee |
| Leodis McKelvin | Oct 1, 2009 | Injured Reserve | Fibula |
| Marcus Buggs | Oct 14, 2009 | Injured Reserve | Knee |
| Kawika Mitchell | Oct 14, 2009 | Injured Reserve | Knee |
| Lydell Sargeant | Oct 22, 2009 | Injured Reserve | Knee |
| Marcus Smith | Oct 22, 2009 | Injured Reserve | Undisclosed |
| Corey McIntyre | Oct 30, 2009 | Out | Knee |
| Trent Edwards | Oct 30, 2009 | Out | Head |
| Shawn Nelson | Oct 30, 2009 | Out | Illness |
| Jonathan Scott | Oct 30, 2009 | Out | Ankle |
| Terrence McGee | Oct 30, 2009 | Probable | Knee |
| Chris Kelsay | Oct 30, 2009 | Probable | Back |
| Bryan Scott | Oct 30, 2009 | Questionable | Ankle |
| Kyle Williams | Oct 30, 2009 | Out | Knee |
| Donte Whitner | Oct 30, 2009 | Out | Ankle |
| Date | Player | Position | Transaction |
|---|---|---|---|
| Oct 14 | Marcus Freeman | LB | Practice squad deletion by Buffalo |
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| Team | W | L | T | PF | PA |
|---|---|---|---|---|---|
| New England | 5 | 2 | 0 | 198 | 98 |
| NY Jets | 4 | 4 | 0 | 177 | 134 |
| Miami | 3 | 4 | 0 | 176 | 177 |
| Buffalo | 3 | 5 | 0 | 123 | 169 |
| Preseason | ||
|---|---|---|
| Week | Date | Opponent |
| Sun 8/9 | Tennessee Titans at Tennessee | L 18 - 21 |
| Sat 8/15 | Chicago Bears Chicago | W 27 - 20 |
| Sat 8/22 | Green Bay Packers at Green Bay | L 21 - 31 |
| Sat 8/29 | Pittsburgh Steelers at Pittsburgh | L 0 - 17 |
| Thu 9/3 | Detroit Lions Detroit | L 6 - 17 |
| Regular Season | ||
|---|---|---|
| Week | Date | Opponent |
| Mon 9/14 | New England Patriots at New England | L 24 - 25 |
| Sun 9/20 | Tampa Bay Buccaneers Tampa Bay | W 33 - 20 |
| Sun 9/27 | New Orleans Saints New Orleans | L 7 - 27 |
| Sun 10/4 | Miami Dolphins at Miami | L 10 - 38 |
| Sun 10/11 | Cleveland Browns Cleveland | L 3 - 6 |
| Sun 10/18 | New York Jets at NY Jets | W 16 - 13 |
| Sun 10/25 | Carolina Panthers at Carolina | W 20 - 9 |
| Sun 11/1 | Houston Texans Houston | L 10 - 31 |
| Bye | ||
| Sun 11/15 | Tennessee Titans at Tennessee | 1:00 pm |
| Sun 11/22 | Jacksonville Jaguars at Jacksonville | 1:00 pm |
| Sun 11/29 | Miami Dolphins Miami | 1:00 pm |
| Thu 12/3 | New York Jets NY Jets | 8:20 pm |
| Sun 12/13 | Kansas City Chiefs at Kansas City | 1:00 pm |
| Sun 12/20 | New England Patriots New England | 1:00 pm |
| Sun 12/27 | Atlanta Falcons at Atlanta | 1:00 pm |
| Sun 1/3 | Indianapolis Colts Indianapolis | 1:00 pm |
| Stat | Player | Total |
|---|---|---|
| PasYds | Trent Edwards | 985 |
| RusYds | Fred Jackson | 445 |
| Rec | Terrell Owens | 23 |
| RecYds | Lee Evans | 331 |
| TD | Lee Evans | 3 |
| Sack | Aaron Schobel | 5.0 |
| Int | Jairus Byrd | 7 |