| Date | Player | Position | Transaction |
|---|---|---|---|
| May 23 | Jeff Locke | SP | Sent to Minors by Pittsburgh |
| May 23 | Jason Grilli | RP | Reinstated from Bereavement/Family Medical Emergency List by Pittsburgh |
| May 21 | Drew Sutton | SS/3B/2B | Traded from Pittsburgh to Tampa Bay (for future considerations) |
| May 21 | Jeff Karstens | SP | Sent to Minors for Rehabilitation by Pittsburgh |
| May 20 | Jeff Locke | SP | Called Up from Minors by Pittsburgh |
| May 20 | Drew Sutton | SS/3B/2B | Traded from Atlanta to Pittsburgh (for cash considerations) |
| May 20 | Jason Grilli | RP | Placed on Bereavement/Family Medical Emergency List by Pittsburgh |
| May 18 | Evan Meek | RP | Sent to Minors by Pittsburgh |
| May 18 | Gorkys Hernandez | LF | Called Up from Minors by Pittsburgh |
| May 16 | Alex Presley | LF/CF | Sent to Minors by Pittsburgh |
| May 16 | Evan Meek | RP | Called Up from Minors by Pittsburgh |
| May 13 | Joel Hanrahan | RP/SP/CL | Reinstated from Bereavement/Family Medical Emergency List by Pittsburgh |
| May 11 | Jeff Larish | 1B/LF/3B | Traded from Boston to Pittsburgh (for cash considerations) |
| May 10 | Daniel McCutchen | RP/SP | Called Up from Minors by Pittsburgh |
| May 10 | Joel Hanrahan | RP/SP/CL | Placed on Bereavement/Family Medical Emergency List by Pittsburgh |
| May 1 | Jared Hughes | RP | Called Up from Minors by Pittsburgh |