| | P | Activated (The Houston Astros activated RHP Cristian Javier from the 15-day injured list.) |
| | P | Designated for Assignment (The Houston Astros designated RHP Brandon Bielak for assignment.) |
| | SS | Activated (The Houston Astros activated INF Grae Kessinger from the 10-day injured list.) |
| | LF | Designated for Assignment (The Houston Astros designated OF Corey Julks for assignment.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RP Alex Speas off waivers from the Oakland Athletics.) |
| | SS | Sent to Minors (The Houston Astros optioned INF Jacob Amaya to the minors.) |
| | LF | Placed on 10-Day IL (The Houston Astros placed OF Chas McCormick on the 10-day injured list.) |
| | 1B | Recalled From Minors Rehab (The Houston Astros recalled INF Trey Cabbage from the minors.) |
| | SS | Recalled From Minors Rehab (The Houston Astros recalled INF Jacob Amaya from the minors.) |
| | 1B | Sent to Minors (The Houston Astros optioned INF José Abreu to the minors.) |
| | SS | Placed on 10-Day IL (The Houston Astros placed INF Grae Kessinger on the 10-day injured list.) |
| | P | Designated for Assignment (The Houston Astros designated RP Joel Kuhnel for assignment.) |
| | 1B | Sent to Minors (The Houston Astros optioned INF Trey Cabbage to the minors.) |
| | CF | Recalled From Minors Rehab (The Houston Astros recalled OF Joey Loperfido from the minors.) |
| | P | Activated (The Houston Astros activated LHP Framber Valdez from the 15-day injured list.) |
| | 1B | Recalled From Minors Rehab (The Houston Astros recalled INF Trey Cabbage from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP J.P. France to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Spencer Arrighetti from the minors.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Cristian Javier on the 15-day injured list with neck discomfort.) |
| | P | Activated (The Houston Astros activated RHP Justin Verlander from the 15-day injured list.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Forrest Whitley to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Forrest Whitley from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Spencer Arrighetti to the minors.) |
| | P | Sent to Minors (The Houston Astros outrighted RHP Wander Suero to the minors.) |
| | P | Activated (The Houston Astros activated RHP Shawn Dubin from the 15-day injured list.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Joel Kuhnel to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RP Joel Kuhnel from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RP Parker Mushinski to the minors.) |
| | P | Signed (The Houston Astros signed RHP Miguel Díaz to a minor league contract.) |
| | P | Signed (The Houston Astros signed RHP Miguel Díaz to a minor league contract.) |
| | P | Declared Free Agency (Houston Astros RHP Miguel Díaz declared free agency.) |
| | P | Sent to Minors (The Houston Astros outrighted RHP Miguel Díaz to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Wander Suero to the minors.) |
| | C | Designated for Assignment (The Houston Astros designated C Cooper Hummel for assignment.) |
| | P | Recalled From Minors Rehab (The Houston Astros selected the contract of RHP Spencer Arrighetti from the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RP Parker Mushinski from the minors.) |
| | P | Sent to Minors (The Houston Astros optioned SP Blair Henley to the minors.) |
| | P | Placed on 15-Day IL (The Houston Astros placed SP Framber Valdez on the 15-day injured list.) |
| | P | Placed on 60-Day IL (The Houston Astros transferred RHP Oliver Ortega from the 15-day injured list to the 60-day injured list.) |
| | P | Recalled From Minors Rehab (The Houston Astros selected the contract of RP Wander Suero.) |
| | P | Recalled From Minors Rehab (The Houston Astros selected the contract of RHP Blair Henley from the minors.) |
| | P | Designated for Assignment (The Houston Astros designated RHP Miguel Díaz for assignment.) |
| | | Traded (The Houston Astros traded RHP Valente Bellozo to the Miami Marlins.) To |
| | P | Placed on 60-Day IL (The Houston Astros placed LHP Bennett Sousa on the 60-day injured list ) |
| | SS | Traded (The Miami Marlins traded INF Jacob Amaya to the Houston Astros.) From |
| | CF | Released (The Houston Astros released OF Justin Dirden.) |
| | P | Sent to Minors (The Houston Astros optioned LHP Parker Mushinski to the minors.) |
| | P | Activated (The Houston Astros activated SP J.P. France off the Paternity List.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Miguel Díaz off waivers.) |
| | P | Placed on 60-Day IL (The Houston Astros placed RHP Luis Garcia on the 60-day injured list as he recovers from right elbow surgery.) |
| | P | Placed on 60-Day IL (The Houston Astros placed RHP Penn Murfee on the 60-day injured list as he recovers from right elbow surgery.) |
| | C | Claimed on Unconditional Release Waivers (The Houston Astros claimed C Cooper Hummel off waivers.) |
| | P | Placed on Restricted List (The Houston Astros placed RHP J.P. France on the paternity list.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RP Dylan Coleman from the minors.) |
| | P | Activated (The Houston Astros activated RHP Bryan Abreu from the suspended list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Luis Garcia on the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Shawn Dubin on the 15-day injured list.) |
| | P | Placed on 60-Day IL (The Houston Astros placed RHP Lance McCullers on the 60-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP José Urquidy on the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Oliver Ortega on the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Justin Verlander on the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed RHP Penn Murfee on the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Houston Astros placed LHP Bennett Sousa on the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Houston Astros selected the contract of RHP Tayler Scott from the minors.) |
| | LF | Sent to Minors (The Houston Astros optioned OF Corey Julks to the minors.) |
| | P | Placed on 60-Day IL (The Houston Astros placed RHP Kendall Graveman on the 60-day injured list.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Penn Murfee off waivers.) |
| | C | Sent to Minors (The Houston Astros sent C C.J. Stubbs to the minors.) |
| | CF | Sent to Minors (The Houston Astros sent OF Pedro Leon to the minors.) |
| | P | Starting to Serve Suspension (Major League Baseball suspended Houston Astros RHP Bryan Abreu for two games.) |
| | C | Sent to Minors (The Houston Astros optioned C César Salazar to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Cole McDonald to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Wander Suero to the minors.) |
| | 2B | Sent to Minors (The Houston Astros optioned INF David Hensley to the minors.) |
| | 1B | Sent to Minors (The Houston Astros optioned INF Trey Cabbage to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Drew Strotman to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Dylan Coleman to the minors.) |
| | CF | Sent to Minors (The Houston Astros sent OF Quincy Hamilton to the minors.) |
| | C | Sent to Minors (The Houston Astros sent C Luke Berryhill to the minors.) |
| | CF | Sent to Minors (The Houston Astros optioned OF Kenedy Corona to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Misael Tamarez to the minors.) |
| | P | Sent to Minors (The Houston Astros optioned RHP Forrest Whitley to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Ray Gaither to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Spencer Arrighetti to the minors.) |
| | 1B | Sent to Minors (The Houston Astros sent INF Chris Gittens to the minors.) |
| | SS | Sent to Minors (The Houston Astros sent INF Dixon Machado to the minors.) |
| | CF | Sent to Minors (The Houston Astros sent OF Jacob Melton to the minors.) |
| | SS | Sent to Minors (The Houston Astros sent INF Zach Dezenzo to the minors.) |
| | C | Sent to Minors (The Houston Astros sent C Miguel Palma to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP A.J. Blubaugh to the minors.) |
| | P | Sent to Minors (The Houston Astros sent RHP Rhett Kouba to the minors.) |
| | P | Sent to Minors (The Houston Astros sent LHP Colton Gordon to the minors.) |
| | 2B | Sent to Minors (The Houston Astros sent INF Will Wagner to the minors.) |
| | P | Signed (The Houston Astros signed RHP Conner Greene to a minor league contract.) |
| | P | Released (The Houston Astros released LHP Brailyn Marquez.) |
| | | Traded (The San Diego Padres traded OF Oliver Carrillo to the Houston Astros.) From |
| | 2B | Signed (The Houston Astros signed INF Jeremy Arocho to a minor league contract.) |
| | 2B | Signed (The Houston Astros signed INF Jeremy Arocho to a minor league contract.) |
| | P | Waived (The Houston Astros waived RHP Declan Cronin.) |
| | 1B | Traded (The Los Angeles Angels traded OF Trey Cabbage to the Houston Astros.) From |
| | P | Designated for Assignment (The Houston Astros designated RHP Declan Cronin for assignment.) |
| | | Traded (The Houston Astros traded RHP Carlos Espinosa to the Los Angeles Angels.) To |
| | P | Non-roster Invitee (The Houston Astros invited RHP Drew Strotman to spring training.) |
| | P | Signed (The Houston Astros signed RHP Drew Strotman to a minor league contract.) |
| | P | Signed (The Houston Astros signed RHP Drew Strotman to a minor league contract.) |
| | P | Signed (The Houston Astros signed LHP Josh Hader.) |
| | P | Designated for Assignment (The Houston Astros designated LHP Matt Gage for assignment.) |
| | SS | Non-roster Invitee (The Houston Astros invited INF Zach Dezenzo to spring training.) |
| | P | Sent to Minors (The Houston Astros sent RHP Joel Kuhnel outright to the minors.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Declan Cronin off waivers from the Chicago White Sox.) |
| | 1B | Signed (The Houston Astros signed INF Chris Gittens to a minor league contract.) |
| | 1B | Signed (The Houston Astros signed INF Chris Gittens to a minor league contract.) |
| | P | Designated for Assignment (The Houston Astros designated RHP Joel Kuhnel for assignment.) |
| | P | Signed (The Houston Astros signed RHP Wander Suero to a minor league contract.) |
| | C | Signed (The Houston Astros signed C Victor Caratini.) |
| | P | Signed (The Houston Astros signed RHP Wander Suero to a minor league contract.) |
| | P | Traded (The Kansas City Royals traded RHP Dylan Coleman to the Houston Astros.) From |
| | P | Traded (The Houston Astros traded RHP Carlos Mateo to the Kansas City Royals.) To |
| | P | Signed (The Houston Astros signed LHP Brailyn Marquez to a minor league contract.) |
| | P | Signed (The Houston Astros signed LHP Brailyn Marquez to a minor league contract.) |
| | SS | Signed (The Houston Astros signed INF Jesús Bastidas to a minor league contract.) |
| | CF | Recalled From Minors Rehab (The Houston Astros selected the contract of OF Kenedy Corona from the minors.) |
| | P | Declared Free Agency ( RHP Matt Ruppenthal declared free agency.) |
| | P | Declared Free Agency (RHP Ronny Garcia declared free agency.) |
| | P | Declared Free Agency (RHP Joe Record declared free agency.) |
| | P | Declared Free Agency (RHP Jake Cousins declared free agency.) |
| | P | Declared Free Agency (RHP Diosmerky Taveras declared free agency.) |
| | C | Declared Free Agency (C Garrett Wolforth declared free agency.) |
| | C | Declared Free Agency (C Andrew Knapp declared free agency.) |
| | 2B | Declared Free Agency (INF Rylan Bannon declared free agency.) |
| | 1B | Declared Free Agency (INF J.J. Matijevic declared free agency.) |
| | P | Declared Free Agency (RHP Enoli Paredes declared free agency.) |
| | P | Declared Free Agency (LHP Juan Lopez declared free agency.) |
| | P | Declared Free Agency (RHP Angel Macuare declared free agency.) |
| | P | Sent to Minors (The Houston Astros sent RHP Enoli Paredes outright to the minors.) |
| | P | Activated (The Houston Astros activated RHP Bryan Abreu.) |
| | P | Declared Free Agency (RHP Hector Neris elected free agency.) |
| | P | Activated (The Houston Astros activated LHP Bennett Sousa.) |
| | P | Activated (The Houston Astros activated RHP Lance McCullers.) |
| | P | Activated (The Houston Astros activated LHP Matt Gage.) |
| | P | Activated (The Houston Astros activated RHP Oliver Ortega.) |
| | LF | Activated (The Houston Astros activated OF Corey Julks.) |
| | P | Activated (The Houston Astros activated RHP Enoli Paredes.) |
| | P | Activated (The Houston Astros activated RHP Kendall Graveman.) |
| | P | Activated (The Houston Astros activated RHP Forrest Whitley.) |
| | C | Activated (The Houston Astros activated C César Salazar.) |
| | 2B | Activated (The Houston Astros activated INF David Hensley.) |
| | P | Activated (The Houston Astros activated LHP Parker Mushinski.) |
| | P | Activated (The Houston Astros activated RHP Seth Martinez.) |
| | P | Activated (The Houston Astros activated RHP Luis Garcia.) |
| | CF | Activated (The Houston Astros activated OF Jake Meyers.) |
| | P | Activated (The Houston Astros activated RHP Brandon Bielak.) |
| | P | Activated (The Houston Astros activated RHP Shawn Dubin.) |
| | P | Activated (The Houston Astros activated RHP Joel Kuhnel.) |
| | P | Declared Free Agency (Houston Astros RHP Phil Maton declared free agency.) |
| | DH | Declared Free Agency (Houston Astros DH Michael Brantley declared free agency.) |
| | P | Declared Free Agency (Houston Astros RHP Ryne Stanek declared free agency.) |
| | C | Declared Free Agency (Houston Astros C Martín Maldonado declared free agency.) |
| | P | Claimed on Unconditional Release Waivers (The Houston Astros claimed RHP Oliver Ortega off waivers from the Minnesota Twins.) |
| | P | Starting to Serve Suspension (Major League Baseball suspended RHP Bryan Abreu for two games.) |
| | CF | Sent to Minors (The Houston Astros optioned OF Jake Meyers to the minors.) |
| | P | Recalled From Minors Rehab (The Houston Astros recalled RHP Ronel Blanco from the minors.) |