Thompson was one of five Warriors players in double-digits as the NBA champions overcame a sluggish start to wrap up a comfortable victory at Oracle Arena.
After an evenly contested first half finished at 58-58, the Warriors produced a breathless burst of scoring in the third quarter to pull clear.
They outscored the Grizzlies by 34 points to 15 in the third, effectively killing off the game going into the fourth.
The victory leaves the Warriors on top of the Western Conference with a 10-1 record.
Point guard Murray drained five three-pointers in his points haul while laying on four assists and hauling down five rebounds.
The victory saw Denver improve to 9-1 to keep pace with the Warriors in the West.
Irving meanwhile was incensed by Murray's late attempt at a three-pointer as the clock ran out in the fourth quarter, grabbing the ball and hurling it into the stands in disgust at the 21-year-old's perceived lack of respect.
"The ball deserves to go in the crowd after a move like that," Irving said. "So I threw it in the crowd."
- 'No disrespect' -
Nuggets head coach Michael Malone denied Murray had been showing disrespect to the Celtics.
"He's young, he's still learning," Malone said.
"You never want to disrespect anyone. I think it wasn't disrespect; he was trying to get to 50 points, which you understand. But our veterans talked to him, and it's something he'll learn from."
The Toronto Raptors maintained their grip on the Eastern Conference standings with a 115-107 win over the Utah Jazz in Salt Lake City.
Raptors point guard Kyle Lowry was the standout performer for the visitors with 17 points, seven rebounds and 11 assists. Toronto star Kawhi Leonard did not play after failing to recover fully from a foot injury.
The Oklahoma City Thunder meanwhile notched their fifth consecutive win at home with a victory over the New Orleans Pelicans but suffered an injury scare to star Russell Westbrook.
Westbrook needed to be helped off court after spraining ankle in the Thunder's 122-116 victory.
The 2017 NBA MVP grimaced in pain after rolling over on his ankle as he landed on Pelicans player Anthony Davis's foot after going up for a rebound in the third quarter.
Westbrook attempted to get up and hobble off on his own but eventually needed assistance as he limped straight to the locker room. The Thunder later said Westbrook appeared to have suffered a sprained left ankle.
Westbrook has only recently returned to action after missing the first two games of the season following knee surgery.
The 29-year-old, who has averaged a triple-double for the past two seasons, had scored 17 points when he left the game, with seven rebounds and nine assists.
Oklahoma City recovered from the loss of their talisman to secure their fifth straight victory and improve to 5-4 for the season.
Paul George scored 23 points and Dennis Schroder weighed in with 22 off the bench as the Thunder hung on for the victory. New Zealander Steven Adams had 18 points.
The Pelicans fell to 4-6 after the loss, with Julius Randle leading the scorers with 26 points.