USA TODAY Sports' Week 4 NFL picks: Tom Brady or Bill Belichick as Buccaneers visit Patriots?

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The showdown the NFL world has been anticipating for more than 18 months will finally unfold Sunday night as Tom Brady and his reigning Super Bowl champion Tampa Bay Buccaneers invade Gillette Stadium in a bid to pillage TB12's employer of 20 seasons, the New England Patriots.

Both teams should be salty coming off Week 3 defeats. But there will certainly be a little more at stake for Brady, who led New England to a record-tying six Super Bowl victories, and Bill Belichick, his former coach and one who was ready to reinvent the Pats with a different signal caller, according to numerous stories that have bubbled up this week.

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A victory will make Brady the fourth player – joining fellow QBs Brett Favre, Peyton Manning and Drew Brees – to beat all 32 NFL teams, and he can take down Brees' mark for career passing yards (80,358) by throwing for 68 in front of a crowd that adored him for two decades.

Who's betting against him?

(Odds provided by Tipico Sportsbook)

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This article originally appeared on USA TODAY: NFL picks Week 4 2021: Tom Brady's Buccaneers vs. Belichick's Patriots