Fuller, a sixth-round pick, unexpectedly won a starting job this season but got hurt last week in Buffalo and didn't practice this week. Rookie running back Cam Akers also missed his second straight game with a rib cartilage injury.
Giants safety Jabrill Peppers is out, as expected.
In Chicago, Indianapolis tight end Trey Burton is set to make his Colts debut against the Bears.
Burton went on injured reserve in early September with a calf injury. He returned to practice Wednesday and was activated on Saturday.
The Colts signed Burton as a free agent in the spring, reuniting him with coach Frank Reich. The two worked together previously in Philadelphia.
Burton spent the past two seasons with the Bears.
NEW YORK GIANTS-LOS ANGELES RAMS
Rams: RB Cam Akers, S Jordan Fuller, C Brian Allen, WR Trishton Jackson, TE Brycen Hopkins, DL Eric Banks.
Vikings: WR Tajae Sharpe, CB Mike Hughes, DE Eddie Yarbrough, T Olisaemeka Udoh and DT James Lynch.
Texans: WR Keke Coutee, CB Cornell Armstrong, FB Cullen Gillaspia, ILB Peter Kalambayi and T Charlie Heck.
Cardinals: QB Brett Hundley, RB Eno Benjamin, S Chris Banjo, S Budda Bake, LB Devon Kennard, OL Josh Miles, OL Josh Jones.
Panthers: QB P.J. Walker, CB Stantley Thomas-Oliver, RB Trenton Cannon, LB Chris Orr, OL Dennis Daley, LT Russell Okung, DT Bravvion Roy.
Saints: WR Michael Thomas, TE Jared Cook, OG Andrus Peat, CB Janoris Jenkins, CB Marshon Lattimore, DE Marcus Davenport, DT Shy Tuttle.
Lions: CB Chris Jones, S C.J. Moore, LB Elijah Lee, OG Logan Stenberg, TE Hunter Bryant.
LA CHARGERS-TAMPA BAY
Chargers: S Jahleel Addae, T Bryan Bulaga, T Storm Norton, WR Joe Reed, QB Tyrod Taylor, G Trai Turner, WR Mike Williams.
Buccaneers: DL Khalil Davis, RB Leonard Fournette, WR Chris Godwin, OLB Cam Gill, QB Ryan Griffin, G Aaron Stinnie.
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