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Spurs take positive momentum into the latter stages of the Champions League, despite starting their campaign with a 2-2 draw against Olympiakos and a 7-2 home thrashing from Bayern Munich, having now won gone unbeaten in their last seven games in all competitions.
Leipzig will be no pushovers though, and Julian Nagelsmann will be equally confident of securing a result.
His side are second in the Bundesliga, only one point off first, and have recently travelled to Borussia Dortmund and Bayern without losing
Here is everything you need to know:
When is the match?
The match kicks off at 8pm at the Tottenham Hotspur Stadium.
What TV channel is it on?
The match will be shown on BT Sport 2 for UK subscribers.
Viewers can also access coverage via the BT Sport App.
Spurs will be without talisman striker Harry Kane and Moussa Sissoko, who both have long-term injuries. Erik Lamela and Juan Foyth could return after absences, but are doubts.
Leipzig have a crisis in defence with Ibrahima Konate and Willi Orban ruled out injured and Dayot Upamecano suspended. Chelsea loanee Ethan Ampadu could feature instead.
Spurs: Lloris, Aurier, Alderweireld, Sanchez, Davies, Lo Celso, Winks, Alli, Bergwijn, Son, Lucas
Leipzig: Gulacsi, Mukiele, Klostermann, Ampadu, Halstenberg, Angelino, Laimer, Sabitzer, Olmo, Nkunku, Werner
Spurs 2-1 RB Leipzig