Toney was listed as questionable on Friday and has not touched the field since Week 15 against the New England Patriots.
Losing Omenihu and Gay would be a huge blow with Omenihu having a remarkable season since joining the team after a six-game suspension with seven sacks in 11 games.
Gay fortifies the middle of the defense with 58 tackles, four tackles for loss, three quarterback hits and a sack.
Omenihu was a full participant in practice all week and Gay had no injury designation until Friday when he was a limited participant.
The 2021 AFC Divisional round rematch is set for 5:30 p.m. on Sunday.