Seattle set a franchise record with 15 3-pointers by the end of the third quarter and finished 17 of 26 from 3-point range.
Rookie Mercedes Russell pushed Seattle over the century mark with 6:32 remaining for a 43-point lead. The Storm didn't score again as the Aces closed on a 16-0 run.
Sue Bird had 11 points and nine assists for Seattle (5-1), which won its fifth straight game for the first time in six seasons. Loyd made five 3-pointers in the first quarter and tied a franchise record with 17 points.
A'ja Wilson scored 21 points for Las Vegas (0-4), which began a stretch of seven games in 12 days. Washington star Kelsey Plum attempted just one shot in 23 minutes in her return to Seattle.