Eight-time Women's Champions League winners Lyon topped Group B by thrashing St Polten.
Ada Hegerberg's first-half double and a goal from Sara Dabritz put Lyon three goals up at the break.
Lyon were constantly on top and Vanessa Gilles, Selma Bacha, Dzsenifer Marozsan each scored in the second half as the French giants relentlessly attacked.
Dabritz capped off a fine evening for Lyon in Austria with her second in the 87th minute to provide Lyon's seventh.
To secure top spot with a match to spare, Lyon needed to match Brann's result against Slavia Prague in the group's earlier game - the Norwegian side winning 1-0.
One round of matches remains but the group has been decided with Brann, who are three points ahead of Slavia Prague, finishing second and qualifying for the quarter-finals.