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Barca will be aiming to record a seventh consecutive victory in all competitions when they entertain Real Valladolid in LaLiga next Tuesday. Meanwhile, Slavia are involved in a huge top-of-the-table clash with Viktoria Plzen in the Czech First League on Sunday.
FULL-TIME: SLAVIA PRAGUE 1-2 BARCELONA
Dembele is shown a yellow card for a professional foul on Kudela.
The hosts continue to push for the equaliser. Their latest attempt sees Soucek's tame header easily gathered by Ter Stegen.
We are into the first of five additional minutes at the end of this game. Can Slavia equalise?
Good save! Messi drives into the heart of the Slavia defence before his bending shot is just tipped away by the outstretched arm of Kolar.
Barca are hanging on as the defence throw their bodies in the way to prevent Slavia from finding a way through. We are set for a grandstand finish in Prague.
A World Cup finalist with Croatia last year, Rakitic has started just one game for Barcelona this season. The midfielder has been linked with a move away from Barca in January, with Inter reportedly the favourites to sign him.
Barca's final substitution sees them turn to experience with Ivan Rakitic replacing Arthur.
The free-kick is played short for Boril to strike, but Barca are quickly out to block him. The subsequent cross is then collected by Ter Stegen.
Slavia have a free-kick right on the edge of the area after Vidal brings down Olayinka. This is a great opportunity for the hosts...
Barca also turn to the bench with Arturo Vidal replacing Busquets.
Meanwhile, Josef Husbauer also enters the action with Stanciu making way.
There is going to be a double change for Slavia. The first sees Mick van Buren replace Masopust.
Sevcik now has his name taken by the referee for dissent at a decision.
We are approaching the final quarter of an hour in Prague, where Barcelona remain 2-1 to the good. Will the visitors hold on for maximum points or can the hosts secure a share of the spoils?
Slavia's frustration is evident as Olayinka is booked for a late challenge on Busquets.
Barca make their first change as Ousmane Dembele is introduced in favour of Griezmann.
Slavia trail again but they do have recent experience of coming from behind to win. They did just that on Saturday to beat Pribram 3-1 in the Czech First League.
Boril has his name taken for his unnecessary challenge on Messi.
There is a break in play as Messi goes down under a heavy challenge from Boril. It was quite unnecessary from the Slavia defender and the Barca players are not too happy with his behaviour.
Football can be a cruel game as Slavia have just discovered. It looked as if they were going to score the third goal of this contest, but the events of the past few minutes have stalled their momentum.
Unlucky! Slavia go straight down the other end and Soucek sends a header just over the bar from close range.
OWN GOAL! BARCELONA LEAD 2-1! The stadium is silenced as Messi's deep free-kick finds Suarez, whose attempted cross deflects past Kolar off the helpless Olayinka.
Masopust has his name taken and Barcelona have a free-kick in a dangerous position with Messi standing over the ball...
Close! The hosts continue to have their tails up and Stanciu tries his luck with a long-range effort that drifts just wide of the target.
That goal has lifted the roof off the Sinobo Stadium. The home fans are really responding to their side, who are very much on top at the moment.
Masopust showed great awareness to find Boril, who did the rest.
EQUALISER!!! BORIL MAKES IT 1-1! Slavia are level and it is courtesy of a very unlikely source! The hosts continue to threaten the Barca defence and Masopust neatly lays the ball into the path of Boril, who pokes a powerful effort beyond a helpless Ter Stegen.
We're off and running again at the Sinobo Stadium!
Slavia make a change at the break with Zeleny making way for Stanislav Tecl.
They may be trailing but, overall, Slavia have held their own against the five-time winners of this event. The hosts must be clinical with any opportunities that fall their way after the break if they are to take anything from the contest.
HALF-TIME: SLAVIA PRAGUE 0-1 BARCELONA
De Jong will be aiming for another impressive year on the continent. His performances for Ajax during the 2018-19 tournament were recognised when he was named the Champions League midfielder of the season.
Alba is the first player to have his name taken after lashing out at Soucek.
The home fans are right behind their team today. Any opportunity to play a team like Barca is one to be embraced and there is a terrific atmosphere at the Sinobo Stadium.
Slavia appear to be growing in confidence and, while trailing by just a single goal, they will sense an opportunity to get back into the contest.
Back on the field, there is a slight concern for Barca as Semedo stays down following a heavy challenge. However, the Portugal international is soon back on his feet and in the thick of the action.
Slavia's number nine has enjoyed a pleasing start to the season. After scoring against Inter in his side's opening group game, he made his debut for Nigeria in their 1-1 draw with Brazil earlier this month.
Barca threaten to get in behind again with Messi leading the charge. However, Olayinka times his sliding challenge to perfection to stop the Barca skipper in his tracks.
Slavia look to respond immediately and a deep cross is delivered towards the far post, where Pique is well-placed to clear the danger.
Well, that will settle the visitors down early on as Messi opens his account in the Champions League this season.
Arthur played a neat return pass into the path of Messi, who made no mistake.
MESSI!! 1-0 BARCELONA! The perfect start for Barca, who pounce on sloppy play from Slavia just outside their own area. Having initially played the ball to Arthur, Messi receives the return pass before neatly steering past a helpless Kolar.
AWAY WE GO! The referee blows his whistle and Slavia get the ball rolling.
The teams are out on the pitch and kick-off is just moments away.