They had been the favourites to win the group, but Luis Enrique’s side drew with Sweden and Poland in their first two games of the tournament, with a missed penalty in the latter ultimately proving costly.
FOLLOW LIVE: Build-up and team news ahead of Slovakia vs Spain
A win is needed to climb into the top two, while a point may see them remain in third or even crash out at the foot of the table if Poland pick up three points against Sweden.
Slovakia started well with a win against Poland but then lost to Sweden in their last match. They were the worse of the two teams in both games but have managed to record three points so far. Another win, or a draw coupled with Sweden not losing, would see them qualify for the next round.
Here’s everything you need to know about the Euro 2020 match.
When is it?
The match will kick off at 5pm BST in Seville.
How can I watch it?
ITV will air the game in the UK, with the ITV Hub platform streaming the match.
Slovakia: Dúbravka, Pekarík, Šatka, Duda, Škriniar, HuboÄan, Hamšík, Haraslín, Kucka, Mak, Hromada
Spain: Simon, Azpilicueta, García, Laporte, Alba, Koke, Busquets, Pedri, Sarabia, Moreno, Morata
Spain have struggled to create clear-cut chances and to score, but they are still the overwhelming favourites for good reason. Slovakia have not performed well so far and now go up against the most difficult test of the group stage. Unless Spain are yet again their own worst enemy, expect a comfortable victory for the hosts here. Slovakia 0-2 Spain.