Which team will get the victory and advance to the Super Bowl?
Check out these NFL playoff picks and predictions for the game, which can be seen at 4:40 p.m. MST on Fox.
The Rams are a 3.5-point favorite in the game.
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Fox Sports: Take the 49ers with the points vs. Rams
Geoff Schwartz writes: "I can’t pick both home teams to win and cover, so I’ll take the Niners here to cover the 3.5, but I think the Rams win outright. The hook is important in this NFC West rivalry game, and I’ll be happy to use it to my advantage. These teams know each other so well, and it’s up to the Rams to not beat themselves down the stretch. It’ll be a close game. Rams win. Niners cover."
Sporting News: Rams 26, 49ers 21
Bill Bender writes: "Samuel will be the X-factor player, too. He averaged 10.8 yards per touch in that Week 18 thriller. The Niners have won the last six meetings in this series, so it's on McVay to make the adjustments necessary to match Shanahan. Will it come with the running game? Akers had a costly late fumble in the divisional victory against the Buccaneers, and Sony Michel needs to be a factor inside. This one plays out a lot like the Week 18 matchup, only this time Stafford stays locked in and the Rams are able to hold on to the lead late. Los Angeles seals its trip to the Super Bowl with a late interception, and Stafford gets his first Super Bowl trip."
Draft Kings: Take the over in Rams vs. 49ers game
Chinmay Vaidya writes: "The first meeting went under this total, with the 49ers winning 31-10. The second meeting went over this total and that’s likely more reflective of how both teams are playing right now. That game did go to overtime, with the 49ers winning 27-24. The Rams have been scoring plenty of points this postseason, and San Francisco’s offense should be better in more favorable playing conditions. Look for there to be plenty of points in this one."
Fansided: Lean toward the Rams in game vs. 49ers
Ben Heisler writes: "The 49ers matched up perfectly against the Packers and got the perfect break when they needed it. I don't see another big break happening again. Back the Rams to become just the second ever team to play a Super Bowl in their home stadium for the second consecutive year after never happening in the previous 55 years beforehand."
Five Thirty Eight: Rams have a 64% win probability
The site gives the 49ers a 36% win probability in the NFL playoff game.
ESPN: Rams have a 59.4% chance to win
The site's Football Power Index gives the 49ers a 40.6% chance to win the NFC Championship Game.
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This article originally appeared on Arizona Republic: San Francisco 49ers vs. Los Angeles Rams picks, predictions playoffs