San Francisco 49ers at Philadelphia Eagles: Game predictions, picks and odds for NFC championship

Jalen Hurts and the top-seeded Philadelphia Eagles will be tasked with defending home turf against Brock Purdy's San Francisco 49ers with a trip to the Super Bowl on the line.

Can the standout 49ers defense — led by standout rusher Nick Bosa — contain Hurts and Co. in the NFC championship game? Will Purdy, surrounded by weapons such as Christian McCaffrey, Deebo Samuel and George Kittle, continue to impress? Or will the Eagles reign supreme? The game is scheduled to kick off Sunday at 3 p.m. ET from Lincoln Financial Field.

Here's a look at the betting details and USA TODAY's NFL staff picks for the 49ers vs. Eagles NFC championship game:

49ers at Eagles odds, moneyline and over/under

  • Spread: Eagles (-2.5)

  • Moneyline: Eagles (-150); 49ers (+130)

  • Over/under: 46.5

  • More odds, injury info for 49ers vs. Eagles

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Lorenzo Reyes: 49ers 23, Eagles 21

In a battle of the league’s top two defenses, I think the 49ers’ ability to generate pressure up the middle and on the edge could potentially stifle Hurts, who appeared to play slightly hesitantly at times in the divisional round when rushing. The 49ers and Kyle Shanahan love attacking the middle of the field, where Philly is weakest on defense. If San Francisco can disrupt the timing of Philadelphia’s offense and speed it up, I think A.J. Brown (who suffered an injury against the Giants) and DeVonta Smith might not be as productive as they normally could be.

Safid Deen: Eagles 30, 49ers 24

The Eagles, the most consistent team all season, return to the Super Bowl behind Hurts and a stout defense, while the 49ers' run with Purdy ends with offensive struggles in Philadelphia.

Richard Morin: 49ers 28, Eagles 23

Is there still some Purdy magic left in the can? I think so. The Eagles' defense struggles with the 49ers' middle-of-the-field attack while the San Francisco defense does just enough disruption to prevent Hurts from accruing consistent chunk yardage.

Jarrett Bell: Eagles 24, 49ers 20

Nate Davis: 49ers 24, Eagles 17

Tyler Dragon: Eagles 21, 49ers 16

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This article originally appeared on USA TODAY: San Francisco 49ers at Philadelphia Eagles: Predictions, picks, odds