McGuire, a second-year pro, is expected to have surgery this week.
"I'm sure it's tough for him going into his second year," Jets coach Todd Bowles said Saturday of McGuire. "Anytime somebody gets hurt, it's a tough break, but he's a hard worker and we expect him to be back as soon as he's ready."
McGuire rushed for 315 yards and one touchdown last season. He was a sixth-round pick out of Louisiana-Lafayette.
The Jets were looking for a replacement Saturday as they worked out veteran free agents Alfred Morris and Orleans Darkwa. Morris is a former two-time Pro Bowler for the Washington Redskins, while Darkwa rushed for 751 yards and five touchdowns for the New York Giants last season.
--Field Level Media