The Bills (3-1) aim to earn their fourth win of the season against a Steelers team in the midst of a quarterback transition from Mitchell Trubisky to rookie Kenny Pickett. Will the first-year QB spark some magic for Pittsburgh, or will the Bills continue to stake their claim as a legitimate playoff threat? The game is set to kick off Sunday at 1 p.m. from Highmark Stadium.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Steelers vs. Bills Week 5 game:
Steelers at Bills odds, moneyline and over/under
Spread: Bills (-13.5)
Moneyline: Bills (-1000); Steelers (+650)
NFL Week 5 predictions, picks and odds
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Lorenzo Reyes: Bills 27, Steelers 17
This is a huge line that Buffalo is capable of covering, but I do think Kenny Pickett brings a little more life into Pittsburgh’s offense. The key for him will be to limit turnovers. Expect the Steelers staff to help him out and craft a game plan that doesn’t ask him to do too much. Pickett’s rushing ability, I think, keeps this closer than two touchdowns.
Safid Deen: Bills 34, Steelers 10
Word of advice to Kenny Pickett in his first career start: Don’t take too much stock in what Josh Allen does on the other side. He’s worked to become one of a kind — and you can, too.
Lance Pugmire: Bills 34, Steelers 17
The week’s widest point spread indicates where this one is going. Steelers coach Mike Tomlin is going to need to summon all of his genius to dig out of a 1-4 hole with a rookie quarterback and preserve his career-long streak without a losing season.
Jarrett Bell: Bills 30, Steelers 17
Nate Davis: Bills 37, Steelers 17
Tyler Dragon: Bills 31, Steelers 13
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This article originally appeared on USA TODAY: Pittsburgh Steelers at Buffalo Bills: Game predictions, picks odds