Pittsburgh Steelers at Buffalo Bills: Predictions, picks and odds for NFL Week 5 matchup

Josh Allen and the Buffalo Bills will look to keep the winning momentum going when they return home to host coach Mike Tomlin's Pittsburgh Steelers.

The Bills (3-1) aim to earn their fourth win of the season against a Steelers team in the midst of a quarterback transition from Mitchell Trubisky to rookie Kenny Pickett. Will the first-year QB spark some magic for Pittsburgh, or will the Bills continue to stake their claim as a legitimate playoff threat? The game is set to kick off Sunday at 1 p.m. from Highmark Stadium.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Steelers vs. Bills Week 5 game:

Steelers at Bills odds, moneyline and over/under

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NFL Week 5 predictions, picks and odds

Colts vs. Broncos | Giants vs. Packers | Falcons vs. Buccaneers | Bears vs. Vikings | Steelers vs. Bills | Lions vs. Patriots | Chargers vs. Browns | Seahawks vs. Saints | Texans vs. Jaguars | Titans vs. Commanders | Dolphins vs. Jets | 49ers vs. Panthers | Eagles vs. Cardinals

Lorenzo Reyes: Bills 27, Steelers 17

This is a huge line that Buffalo is capable of covering, but I do think Kenny Pickett brings a little more life into Pittsburgh’s offense. The key for him will be to limit turnovers. Expect the Steelers staff to help him out and craft a game plan that doesn’t ask him to do too much. Pickett’s rushing ability, I think, keeps this closer than two touchdowns.

Buffalo Bills wider receiver Isaiah McKenzie (6) greeted by quarterback Josh Allen (17) after his second quarter touchdown against the Baltimore Ravens at M&T Bank Stadium.
Buffalo Bills wider receiver Isaiah McKenzie (6) greeted by quarterback Josh Allen (17) after his second quarter touchdown against the Baltimore Ravens at M&T Bank Stadium.

Safid Deen: Bills 34, Steelers 10

Word of advice to Kenny Pickett in his first career start: Don’t take too much stock in what Josh Allen does on the other side. He’s worked to become one of a kind — and you can, too.

Lance Pugmire: Bills 34, Steelers 17

The week’s widest point spread indicates where this one is going. Steelers coach Mike Tomlin is going to need to summon all of his genius to dig out of a 1-4 hole with a rookie quarterback and preserve his career-long streak without a losing season.

Jarrett Bell: Bills 30, Steelers 17

Nate Davis: Bills 37, Steelers 17

Tyler Dragon: Bills 31, Steelers 13

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This article originally appeared on USA TODAY: Pittsburgh Steelers at Buffalo Bills: Game predictions, picks odds