The Pats center was helped to the locker room during the first quarter after sustaining what the team confirmed to be a thigh injury. He was later ruled out for the remainder of the game.
Andrews missed the Patriots' previous two games after suffering a head injury on a blindside hit during their Week 8 loss to the Chicago Bears. Bears defensive tackle Mike Pennel was ejected for the hit, Patriots co-captain Matthew Slater called an "extremely dirty play."
If Andrews is forced to miss more time, it would be a significant blow to a Patriots offensive line that has struggled mightily this season. Fellow lineman Isaiah Wynn also left Sunday's game with a foot injury and was ruled out.