Lazard had said Thursday he doubted that he'd be available to play against the Bills after injuring his shoulder in a 23-21 loss at Washington. The Packers released an injury report Friday that removed all suspense by declaring Lazard and reserve cornerback Shemar Jean-Charles out.
The Packers labeled offensive tackle David Bakhtiari (knee), offensive lineman Elgton Jenkins (knee/foot), wide receiver Christian Watson (hamstring) and outside linebacker Rashan Gary (concussion) questionable.
Watson has missed two straight games and has been a limited practice participant all week. Bakhtiari, who didn't play at Washington, practiced on a limited basis Wednesday and Friday but missed Thursday's session.
Gary practiced fully Friday, and Jenkins was a limited participant.
Lazard has 26 catches for 340 yards and four touchdowns to lead Packers receivers in the latter two categories. Gary has a team-high six sacks.
The Packers (3-4) will be attempting to snap a three-game skid when they face the Bills (5-1).
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