The Hoyas (12-6, 2-3 Big East) went on a 13-2 run early in the second half and never looked back as coach Patrick Ewing picked up his first win over the Bluejays in five tries.
Georgetown, a three-point favorite, snapped a five-game losing streak to Creighton and beat a ranked opponent for the second time this season.
Marcus Zegarowski led the Bluejays (13-5, 2-3) with 20 points while Denzel Mahoney added 19 off the bench. Creighton lost for the first time this season when scoring at least 70 points (12-1).
Creighton trailed by as many as nine at 70-61 but used an 8-0 run capped off by Mitch Ballock's 3-pointer to cut the deficit to 70-69.
Georgetown held a 41-29 advantage on the glass to make up for a big difference in 3-point shooting. Creighton made 13 of 32 shots from deep while the Hoyas were just 5 for 15. Zegarowski only connected from deep, making 6 of 11 3-pointers and finishing 6 for 15 overall.
Yursteven had his ninth double-double of the season.
Jagan Mosely added 13 points while Jahvon Blair had 12 for Georgetown.
Creighton: Ranked for the first time since also appearing at No. 25 on Jan. 8, 2017, the Bluejays trailed for most of the second half in falling to under .500 in the conference. Their stay in the AP Top 25 could be short.
Georgetown: The Hoyas have won both conference games at home while scoring more than 80 points and have lost all three on the road while scoring less than 70.
Creighton: Returns home to host Providence on Saturday. The Bluejays swept the Friars last season, including a 76-70 overtime win in Omaha.
Georgetown: The Hoyas host Marquette on Saturday in their annual Gray Out game. The two schools split their series last season with both winning on the other team's home court.
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Omer Yurtseven's double-double leads Hoyas over No. 25 Creighton originally appeared on NBC Sports Washington