Morgahn Fingall recorded 17 kills, seven digs, one assist, one ace and one block for the Lady Vols.
Jenaisya Moore totaled 11 kills and three blocks, while Erykah Lovett recorded eight kills and one ace for Tennessee.
Yelianiz Torres totaled 21 digs, four assists and one ace, while Caroline Kerr had 40 assists and 15 digs for the Lady Vols.
Raeven Chase finished the match with five blocks for Tennessee.
The Lady Vols have defeated Missouri two times this season. Tennessee defeated the Tigers, 26-24, 25-19, 25-11 in Thompson-Boling Arena at Food City Center.