| | RB | Signed/unrest FA (One-year contract (through 2018)) From |
| | CB | Signed/unrest FA (One-year contract (through 2018)) To |
| | TE | Signed (One-year contract (through 2018)) From |
| | DT | Signed/unrest FA (One-year contract (through 2018)) To |
| | RB | Cut (Signed) |
| | S | Signed (One-year contract (through 2018)) From |
| | WR | Signed (One-year contract (through 2018)) From |
| | QB | Signed (Signed) From |
| | LB | Signed (One-year contract (through 2018)) To |
| | CB | Signed/unrest FA (One-year contract (through 2018)) To |
| | LB | Signed/unrest FA (Two-year contract (through 2019)) To |
| | LB | Signed/unrest FA (One-year contract (through 2018)) To |
| | RB | Signed/unrest FA (One-year contract (through 2018)) From |
| | DT | Re-signed/unrest FA (One-year contract (through 2018)) |
| | NT | Signed (Two-year contract (through 2019)) From |
| | G | Re-signed/unrest FA (One-year contract (through 2018)) |
| | QB | Signed/unrest FA (One-year contract (through 2018)) To |
| | QB | Signed/unrest FA (Two-year contract (through 2019)) From |
| | DE | Re-signed/unrest FA (One-year contract (through 2018)) |
| | C | Signed/unrest FA (Four-year contract (through 2021)) To |
| | P | Re-signed/unrest FA (Three-year contract (through 2020)) |
| | RB | Re-signed/unrest FA (One-year contract (through 2018)) |
| | CB | Signed/unrest FA (Three-year contract (through 2020)) To |
| | WR | Signed/unrest FA (Three-year contract (through 2020)) To |
| | LB | Signed/unrest FA (Five-year contract (through 2022)) From |
| | QB | Traded (for CB Kendall Fuller and draft pick) To |
| | WR | Signed/unrest FA (Three-year contract (through 2020)) From |
| | P | Declared Free Agent (Signed) |
| | DE | Restricted Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | DT | Declared Free Agent (Signed) |
| | CB | Traded (w/ pick for 2018 and 2019 picks) To |
| | WR | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | LB | Re-signed (One-year contract (through 2018)) |
| | WR | Declared Free Agent (Signed) |
| | C | Declared Free Agent (Signed) |
| | QB | Declared Free Agent (Signed) |
| | WR | Re-signed/unrest FA (One-year contract (through 2018)) |
| | DT | Declared Free Agent (Signed) |
| | CB | Declared Free Agent (Signed) |
| | CB | Traded (w/ 3rd-round pick for QB Alex Smith) From |
| | S | Declared Free Agent (Signed) |
| | G | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | RB | Declared Free Agent (Signed) |
| | DE | Declared Free Agent (Signed) |
| | RB | Declared Free Agent (Signed) |
| | LB | Declared Free Agent (Signed) |
| | S | Cut (Signed) |
| | RB | Re-signed (Signed) |
| | LB | Cut (Signed) |
| | CB | Signed (One-year contract (through 2018)) From |
| | CB | Cut (Signed) |
| | LB | Activated from PUPL (Signed) |
| | S | Reinstated (Signed) |
| | WR | Signed (Signed) To |
| | DT | Signed (Signed) From |
| | T | Signed (Signed) To |
| | DE | Signed (Signed) To |
| | TE | Signed (Signed) From |
| | CB | Signed (Signed) |
| | NT | Signed (Signed) |
| | G | Signed (Signed) |
| | DE | Signed (Signed) |
| | T | Signed (Signed) |
| | TE | Signed (Signed) |
| | WR | Signed (Signed) |
| | WR | Signed (Signed) |
| | RB | Signed (Signed) |
| | T | Signed (Signed) |
| | CB | Signed (Signed) From |
| | G | Signed (Signed) To |
| | CB | Signed (Signed) From |
| | DT | Signed (Signed) To |
| | DT | Signed (Signed) From |
| | DT | Signed (Signed) From |
| | WR | Signed (Signed) From |
| | CB | Signed (Signed) From |
| | WR | Pract. squad add (Signed) From |
| | RB | Signed (Signed) |
| | WR | Active/prac. squad (Signed) |
| | WR | Signed (Signed) To |
| | T | Pract. squad add (Signed) From |
| | T | Pract. squad add (Signed) To |
| | DT | Pract. squad add (Signed) To |
| | K | Signed (Signed) To |
| | LB | Pract. squad add (Signed) To |
| | WR | Pract. squad add (Signed) To |
| | CB | Pract. squad add (Signed) To |
| | CB | Active/prac. squad (Signed) |
| | DT | Pract. squad del (Signed) |
| | DE | Pract. squad add (Signed) From |
| | G | Pract. squad add (Signed) From |
| | G | Active/prac. squad (Signed) To |
| | T | Pract. squad add (Signed) From |
| | S | Active/prac. squad (Signed) |
| | CB | Suspension lifted (Signed) |
| | DT | Active/prac. squad (Signed) From |
| | CB | Suspended (1 game (by team - on-field conduct)) |
| | WR | Pract. squad add (Signed) To |
| | CB | Pract. squad add (Signed) To |
| | WR | Pract. squad del (Signed) |
| | TE | Pract. squad add (Signed) From |
| | NT | Pract. squad add (Signed) From |
| | TE | Active/prac. squad (Signed) |
| | TE | Acquired from waiver (Signed) To |
| | TE | Cut (Signed) |
| | DT | Cut (Signed) |
| | CB | Signed (Signed) From |
| | K | Signed (Signed) To |
| | T | Pract. squad add (Signed) To |
| | T | Cut (Signed) |
| | DT | Cut (Signed) |
| | DT | Pract. squad add (Signed) |
| | DT | Signed (Signed) |
| | DE | Active/prac. squad (Signed) To |
| | T | Pract. squad del (Signed) |
| | CB | Pract. squad add (Signed) From |
| | WR | Pract. squad del (Signed) |
| | WR | Pract. squad add (Signed) From |
| | CB | Acquired from waiver (Signed) To |
| | LB | Activated from PUPL (Signed) |
| | CB | Cut (Signed) |
| | TE | Active/prac. squad (Signed) To |
| | TE | Pract. squad add (Signed) |
| | RB | Cut (Signed) |
| | T | Pract. squad add (Signed) From |
| | TE | Signed (Signed) To |
| | CB | Cut (Signed) |
| | WR | Pract. squad add (Signed) |
| | WR | Cut (Signed) |
| | RB | Signed (Signed) |
| | G | Active/prac. squad (Signed) To |
| | WR | Active/prac. squad (Signed) |
| | WR | Pract. squad add (Signed) From |
| | LB | Pract. squad del (Signed) |
| | TE | Pract. squad del (Signed) |
| | TE | Pract. squad add (Signed) From |
| | QB | Pract. squad add (Signed) To |
| | C | Signed (Signed) To |
| | K | Cut (Signed) |