| Player | Rushing Yards |
|---|---|
| Emmitt Smith | 18,355 |
| Walter Payton | 16,726 |
| Barry Sanders | 15,269 |
| Curtis Martin | 14,101 |
Frank Gore* | 14,026 |
| LaDainian Tomlinson | 13,684 |
| Jerome Bettis | 13,662 |
| Eric Dickerson | 13,259 |
| Tony Dorsett | 12,739 |
| Jim Brown | 12,312 |
| Marshall Faulk | 12,279 |
| Adrian Peterson | 12,276 |
| Edgerrin James | 12,246 |
| Marcus Allen | 12,243 |
| Franco Harris | 12,120 |
| Thurman Thomas | 12,074 |
| Fred Taylor | 11,695 |
| Steven Jackson | 11,435 |
| John Riggins | 11,352 |
| Corey Dillon | 11,241 |
| O.J. Simpson | 11,236 |
| Warrick Dunn | 10,967 |
| Ricky Watters | 10,643 |
| Jamal Lewis | 10,607 |
| Thomas Jones | 10,591 |
| Tiki Barber | 10,449 |
| Eddie George | 10,441 |
| Ottis Anderson | 10,273 |
LeSean McCoy* | 10,092 |
| Ricky Williams | 10,009 |
Marshawn Lynch* | 10,003 |
| Clinton Portis | 9,923 |
| Matt Forte | 9,796 |
| Joe Perry | 9,723 |
| Chris Johnson | 9,651 |
| Shaun Alexander | 9,453 |
| Earl Campbell | 9,407 |
| Ahman Green | 9,205 |
| Terry Allen | 8,614 |
| Jim Taylor | 8,597 |
| Willis McGahee | 8,474 |
| Earnest Byner | 8,261 |
| Herschel Walker | 8,225 |
| Roger Craig | 8,189 |
| Gerald Riggs | 8,188 |
| Priest Holmes | 8,172 |
| Maurice Jones-Drew | 8,167 |
| DeAngelo Williams | 8,096 |
| Larry Csonka | 8,081 |
| Freeman McNeil | 8,074 |
| Stephen Davis | 8,052 |
| Garrison Hearst | 7,966 |
| James Brooks | 7,962 |
| Chris Warren | 7,696 |
| Terrell Davis | 7,607 |
| Jamaal Charles | 7,556 |
| Mike Pruitt | 7,378 |
| Michael Turner | 7,338 |
Jonathan Stewart* | 7,318 |
| Leroy Kelly | 7,274 |
| George Rogers | 7,176 |
| DeMarco Murray | 7,174 |
| Charlie Garner | 7,097 |
| Rodney Hampton | 6,897 |
| Antowain Smith | 6,881 |
| Curt Warner | 6,844 |
| Robert Smith | 6,818 |
| John Henry Johnson | 6,803 |
| Wilbert Montgomery | 6,789 |
| Chuck Muncie | 6,702 |
| Mark van Eeghen | 6,651 |
| Lawrence McCutcheon | 6,578 |
| Lydell Mitchell | 6,534 |
| Arian Foster | 6,527 |
| Wendell Tyler | 6,378 |
| Brian Westbrook | 6,335 |
| Floyd Little | 6,323 |
| Larry Johnson | 6,223 |
| Don Perkins | 6,217 |
| Ray Rice | 6,180 |
| Neal Anderson | 6,166 |
| Mike Vick | 6,109 |
| Ken Willard | 6,105 |
| Deuce McAllister | 6,096 |
| Travis Henry | 6,086 |
| Calvin Hill | 6,083 |
| Cedric Benson | 6,017 |
| James Wilder | 6,008 |
| William Andrews | 5,986 |
| Rudi Johnson | 5,979 |
| Chuck Foreman | 5,950 |
LeGarrette Blount* | 5,888 |
| Larry Brown | 5,875 |
| Steve Van Buren | 5,860 |
| James Stewart | 5,841 |
| Bill Brown | 5,838 |
| Rick Casares | 5,797 |
| Duce Staley | 5,785 |
| Fred Jackson | 5,746 |
| Greg Pruitt | 5,672 |