The Rams will look to buck a trend that has plagued them for decades.
When the Rams moved from Los Angeles to St. Louis in 1995, they were in the middle of a 17-game losing streak to the 49ers that lasted from 1990-98.
The Rams finally righted things in 1999, winning six straight and 10 of 12 against San Francisco (still, the 49ers owned a 25-16-1 advantage while the Rams were in St. Louis). Now that the Rams are back in Los Angeles, the 49ers have won three straight in the series. While the Rams were 4-12 last season, both of 2-14 San Francisco's wins came at the Rams' expense.
The 49ers (0-2) have scored just 12 points on four field goals this year. The Rams (1-1), conversely, have scored 66 points behind an opportunistic defense and efficient play from second-year quarterback Jared Goff while Todd Gurley once again looks like a Pro Bowl-caliber running back.
The Rams should win Thursday, but their last visit to Levi's Stadium did not go well as the Niners pulled off a 28-0 upset in last year's opener. Carlos Hyde, who has 169 rushing yards so far, ran for 88 and two scores in the 2016 opener.
After the Rams and Niners square off at Levi's Stadium, the NFL's Week 3 schedule continues in London. Here's a look at the weekend's marquee games:
Ravens (2-0) vs. Jaguars (1-1), 9:30 a.m. ET Sunday (Yahoo)
Jacksonville — the home team at London's Wembley Stadium — has the offensive weapons to give the Ravens fits; it's just a matter of whether or not quarterback Blake Bortles can take care of the ball.
Raiders (2-0) at Redskins (1-1), 8:30 p.m. Sunday (NBC)
The Raiders, who bring one of the NFL's best offenses with them, lead the NFL with 71 points as Derek Carr is completing 75 percent of his passes for 492 yards and five touchdowns with zero interceptions. The Redskins can't just focus on trying to shut down Oakland's air attack because Raiders running back Marshawn Lynch is looking like "Beast Mode" again.
The best way for Washington to pull off the upset is to control the clock, which puts the onus on quarterback Kirk Cousins and running back Rob Kelley to help out their defense.
Cowboys (1-1) at Cardinals (1-1), 8:30 p.m. Monday (ESPN)
Following a disappointing effort in a 42-17 loss to the Broncos, Cowboys running back Ezekiel Elliott will look to get on track against a Cardinals defense that has been stout against the run. Arizona has allowed just 79 rushing yards per game, good for 10th in the league.
Second-year Cowboys quarterback Dak Prescott, who also struggled against the Broncos, will try to soften the Cardinals defense through the air to set up Elliott on the ground.