NFL picks: Experts predict Jaguars vs. 49ers in Week 10

The Jacksonville Jaguars will be underdogs Sunday against the San Francisco 49ers, but should they be?

It’s the 49ers on a three-game losing streak after starting the year 5-0. And it’s the Jaguars who own the NFL’s longest win streak after coming out on top of all five of their October contests.

A Week 9 bye for both teams provided time for several key players to get healthy, and it may have also been the reset the 49ers needed to get back on track. A big trade to acquire Chase Young from the Washington Commanders didn’t hurt either.

But was that enough to give the 49ers the edge in Week 10. Here’s what experts predict will happen Sunday at EverBank Stadium:

USA Today

Nathan Ray Seebeck-USA TODAY Sports
Nathan Ray Seebeck-USA TODAY Sports

USA Today’s Week 10 picks

Jarrett Bell: 49ers, 26-21

Chris Bumbaca: 49ers, 24-23

Nate Davis: 49ers, 30-23

Safid Deen: Jaguars, 34-30

Tyler Dragon: 49ers, 24-20

Victoria Hernandez: 49ers, 24-23

Michael Middlehurst-Schwartz: Jaguars, 23-20

Lorenzo Reyes: 49ers, 25-20

Ken Blaze-USA TODAY Sports
Ken Blaze-USA TODAY Sports’s Week 10 picks

Ali Bhanpuri: 49ers, 26-24

Brooke Cersosimo: 49ers, 27-23

Dan Parr: 49ers, 24-20

Gennaro Filice: 49ers, 30-20

Tom Blair: 49ers, 24-22


Bob Self/Florida Times-Union
Bob Self/Florida Times-Union

ESPN’s Week 10 picks

Stephania Bell: 49ers

Matt Bowen: 49ers

Mike Clay: Jaguars

Dan Graziano: Jaguars

Kimberley Martin: 49ers

Eric Moody: 49ers

Jason Reid: 49ers

Lindsey Thiry: 49ers

Sam Wickersham: 49ers

CBS Sports

Corey Perrine/Florida Times-Union
Corey Perrine/Florida Times-Union

CBS Sports’ Week 10 picks

Pete Prisco: Jaguars

Will Brinson: Jaguars

Jared Dubin: 49ers

Ryan Wilson: Jaguars

John Breech: 49ers

Tyler Sullivan: 49ers

Dave Richard: 49ers

Jamey Eisenberg: Jaguars

Sporting News

Matthew Hinton-USA TODAY Sports
Matthew Hinton-USA TODAY Sports

Bill Bender

How do the 49ers emerge from the bye week after a three-game losing streak? The Young trade should help bolster the pass rush, and Deebo Samuel (shoulder) could return this week. Brock Purdy has thrown five interceptions through the losing streak. Trevor Lawrence has a 70% completion percentage with six TDs and two interceptions through the streak. This could easily be the best game of the week. The line has ticked up a half-point. We are going to take the 49ers.

Pick: 49ers 26, Jaguars 20

Bleacher Report

Corey Perrine/Florida Times-Union
Corey Perrine/Florida Times-Union

Bleacher Report’s Week 10 picks

Gary Davenport: Jaguars

Brad Gagnon: 49ers

Ian Hanford: 49ers

Kris Knox: Jaguars

Maurice Moton: 49ers

Wes O’Donnell: Jaguars

Brent Sobleski: Jaguars

Bottom Line

Melina Myers-USA TODAY Sports
Melina Myers-USA TODAY Sports

San Francisco is slightly favored on the road and most experts evidently think it’s justified. Here’s the final tally:

49ers: 26

Jaguars: 12

Story originally appeared on Jaguars Wire