NFL DFS Single Games: MNF Week 10

Spencer Limbach

Here we go with the Single Game NFL DFS slate for Monday Night Football of Week 10. Tonight’s matchup is between the Seahawks and 49ers, as San Francisco is listed as six-point home favorites with an over/under of 47.5.  

We’ll highlight the top picks and best bargains to assemble a cash-inducing lineup. On top of that, the “additional notes” section will feature several tournament selections while adding context to the rest of this slate. 

We will be producing these articles for Thursday, Sunday, and Monday primetime matchups every week, so be sure to bookmark the Rotoworld Daily page for those occasions - not to mention all the other fantastic daily fantasy content. 


Jimmy Garoppolo - QB - San Francisco 

This slate is hardly straightforward, and it largely depends on which DFS site you are playing on. Jimmy Garoppolo makes for a strong MVP choice on FanDuel, where you don’t have to pay the 1.5x salary multiplier for a bonus. Seattle has allowed the 11th most fantasy points to opposing quarterbacks, and they tend to funnel production through the air. Furthering that point, the Seahawks rank 29th in overall pass defense and 13th against the run. This could be another situation where the 49ers actually lean on Jimmy G, which resulted in 29 fantasy points last Thursday (albeit in a better matchup). While we aren’t expecting a repeat performance, Garoppolo has a good chance to post the top fantasy score of the night. 

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Russell Wilson - QB - Seattle 

San Francisco has one of the best defenses in the NFL, but they also haven’t faced a quarterback of Russell Wilson’s caliber. The real-life MVP candidate competes with Garoppolo as the top overall fantasy choice in this single game slate, even though the matchup looks brutal on paper. Still, the Seahawks’ offense is so highly concentrated through Wilson/Carson that he demands a look as Captain/FLEX on all sites. Take your favorite QB as the top option on FanDuel (I’m leaning Garoppolo), but it makes sense to run with a cheaper selection as Captain on DraftKings (Carson for cash?) while stacking both quarterbacks in FLEX spots. 


Ross Dwelley - TE - San Francisco 

George Kittle is doubtful for tonight’s contest. We aren’t exactly sure how the 49ers will replace their All-Pro tight end, as Ross Dwelley, Kyle Juszcyk, and Levine Toilolo could all play a role. Dwelley held a 70% snap rate last week (second-highest on the team) while drawing five targets (4-29). He’s nothing more than a value filler, and his role is undefined heading into this matchup. However, there’s upside if he sees more looks in Kittle’s absence, which demands attention for a dirt-cheap salary. 

Chase McLaughlin - K - San Francisco 

Jason Myers - K - Seattle

The kickers make sense as fallback options in a game like this. McLaughlin isn’t even listed on FanDuel, as he’s filling in for Robbie Gould (doubtful) this week. Myers could see more work than usual while facing a legitimate San Francisco defense (putting it mildly) that should disrupt Seattle’s red-zone efficiency. Myers’ projection is marginally higher, and I’m in agreement with that. 


Chris Carson (RB - SEA) certainly belongs in the “top picks” section alongside both quarterbacks. That especially holds true on DraftKings, where the salary cap is tight, and he’s much cheaper than the signal-callers. Sure, the matchup is brutal, but Carson should see plenty of volume via the passing and running game alongside valuable goal-line touches. He’s a Captain choice on DraftKings (due to price) while gaining FLEX recognition on FanDuel. 

Tyler Lockett (WR - SEA) is the third-best fantasy receiver in terms of PPR scoring this season. However, he’s tasked with a brutal matchup against CB K’Waun Williams, who has allowed the fourth-lowest passer rating to the slot (51 qualified players). Lockett still has the raw talent to make some fantasy noise, and having one of the best QBs in the league throwing his way doesn’t hurt. He’s borderline cash playable, but a solid tournament mixer when building multiple entires … DK Metcalf (WR - SEA) is more of a boom-or-bust tournament option, but I don’t mind him as the final piece of a cash game puzzle if his salary works. After all, the rookie is a deep threat with 13 red-zone targets to boot … Josh Gordon (WR - SEA) and Jacob Hollister (TE - SEA) are nothing more than tournament longshots. Gordon is technically a game-time decision, even though early reports suggest he’ll play. We aren’t sure what his snap rate will look like after recently joining the Seahawks. He’s probably better as a wait-and-see commodity, even when assembling a large number of tournament entries. Hollister’s salary has been marked-up after coming through with a pair of scores against the Bucs. That makes him difficult to stomach in anything more than multi-entry formats, as the matchup is truly horrible. 

Emmanuel Sanders (WR - SF) makes sense as a stack through all formats when rostering Garoppolo as well. Sanders played 95% of the snaps last week, coming through with a sweet 7-112-1 showing. As mentioned earlier, Seattle is vulnerable to the pass, and the likely absence of Kittle could boost Sanders even more … Deebo Samuel (WR - SF) is next-in-line for the San Francisco passing game, serving as a tournament differentiator (or cheaper bargain) away from Sanders … Dante Pettis (WR - SF) and Marquise Goodwin (WR - SF) are nothing more than tournament stacks of Garoppolo, who you are hoping come through with big plays on limited targets. 

The best way to beat Seattle is through the air, leaving Tevin Coleman (RB - SF) and Matt Breida (RB - SF) as borderline cash options who are probably better in tournaments. Coleman’s touchdown upside is more intriguing, but that is baked into a higher overall salary as well … Kyle Juszczyk (RB - SF) is a tournament filler who could be tasked with more responsibility sans Kittle. Still, it’s a true roll of the dice as to whether or not he finds more fantasy success from that. 

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