Andy Pettitte has fared well against Chris Davis, but baseball's home run leader did take him deep earlier this year like he's done to so many pitchers.
Davis looks for his 50th homer Wednesday night against Pettitte when the Baltimore Orioles continue this crucial four-game set against the visiting New York Yankees, who will be without Derek Jeter for the rest of the season.
Baltimore (77-67) is 1 1/2 games behind Tampa Bay for the AL's second wild card, and New York (77-68) and Cleveland are two games back. The Yankees, though, made an announcement hours before this matchup that Jeter's season is over due to a nagging ankle injury.
Jeter started the year on the disabled list after breaking his left ankle in the 2012 playoffs. He played in only 17 games, batting .190 with one homer and seven RBIs.
"It's very disappointing not to be able to play, especially at this time of year," Jeter said. "This is when I want to play the most."
Davis hit his 49th homer Tuesday, but the Yankees evened the series with a 7-5 victory and will send Pettitte (10-9, 4.03 ERA) to the mound Wednesday.
Pettitte is 8-0 with a 2.99 ERA in his last 12 regular-season starts against the Orioles. He yielded three runs over seven innings in a 3-2 defeat in a Game 2 loss at Camden Yards in last year's division series.
That's the last time the left-hander pitched in Baltimore, where he owns a 16-4 mark for the most victories by a visiting pitcher at Camden Yards.
He is 1-0 with a 3.55 ERA in two starts against the Orioles this year. Davis is 1 for 6 in those games with a first-inning homer July 6 and is 3 for 13 overall against Pettitte.
The slugger hit a two-run shot in the fifth inning Tuesday to give Baltimore a 4-1 lead. He's one shy of Brady Anderson's franchise record set in 1996.
The Yankees responded with two runs in the sixth inning and four in the eighth. Alfonso Soriano hit two home runs and former Baltimore slugger Mark Reynolds also went deep.
Soriano has 15 homers and 47 RBIs in 43 games with New York, which acquired him from the Cubs on July 26. He needs two RBIs to reach 100 for the fourth time.
"They made a good acquisition," Baltimore manager Buck Showalter said. "He's been a good player for a long time. It's a good pickup for them."
Soriano will face another player who began 2013 with the Cubs in Scott Feldman (5-4, 3.63), who yielded one run over seven innings in a 1-0 loss Aug. 31 at Yankee Stadium. The right-hander is 3-4 with a 3.58 ERA in seven career starts against New York.
Feldman has a 1.31 ERA in winning his last three outings at Camden Yards, including a five-hitter for his first career shutout in a 4-0 victory over the White Sox on Friday.
"If I go nine or seven, whatever it is, as long as we win it's a good game," he said.
Curtis Granderson is 6 for 14 off Feldman, Vernon Wells is 7 for 14 and Soriano is 0 for 3.
Alex Rodriguez, 4 for 8 with a homer and two doubles in this series, is 4 for 13 against Feldman. The third baseman exited Tuesday after he experienced tightness in his left hamstring.
"I iced it," Rodriguez said. "It feels pretty good right now."
The Yankees announced after Tuesday's win that they have acquired slick-fielding shortstop Brendan Ryan from Seattle for a player to be named, and he's in the starting lineup for this game.
Catcher Austin Romine also left Tuesday due to a concussion.
The Yankees expect David Robertson to be available Wednesday. The reliever had tendinitis in the back of his right shoulder and hasn't pitched since Thursday.
Adam Jones is 8 for 23 against Pettitte while Matt Wieters is 2 for 12. Nick Markakis is 0 for 7 this year off the lefty and expects to play even though his wife is expected to induce labor Wednesday morning.