TORONTO (AP) -- The Raptors put a winning punctuation mark on a stretch of games against struggling opponents.
Their next six contests will provide a significantly greater challenge.
Toronto, which leads the East at 22-6, visits Chicago on Monday, the first game on a season-high, six-game road trip that finishes with five against Western Conference opponents.
''We're looking forward to this challenge,'' Toronto's Greivis Vasquez said. ''Any time you go to the West it's not easy, but I think we're good enough to come out with a couple of wins and do our job. We've got to remain humble and hungry and continue to work.''
With the World Junior Hockey Championships moving into Air Canada Centre over the holidays, the Raptors won't play at home again until Jan. 8 against Charlotte. After Chicago, they'll visit the Clippers, Denver, Portland, Golden State and Phoenix.
''We should be ready for it because we've been preaching it,'' Raptors coach Dwane Casey said.
The challenging stretch will be made even more difficult by the ongoing absence of leading scorer DeMar DeRozan, who remains sidelined with a torn tendon in his left groin. Toronto has gone 9-3 without DeRozan, whose return date is unknown.
''We're playing for a lot of different things but mainly we want our franchise player back,'' Vasquez said. ''We need him. It's unfair if you're going to analyze us without our best scorer.''
Vasquez had 21 points and Terrence Ross scored 18 for the Raptors, who never trailed in matching their longest winning streak of the season. Toronto also won six straight from Nov. 15 to 26.
Carmelo Anthony scored 28 for the Knicks, who lost their fifth straight and have dropped 15 of 16 overall. Jason Smith had 16 points and Jose Calderon finished with 15 points and 10 assists.
Anthony acknowledged finding it hard to fathom that the Knicks are 20 games below .500 at 5-25.
''It doesn't seem real,'' he said.
New York fell to 2-13 on the road and 1-6 in the second game of back-to-backs. The Knicks lost 99-90 at home to Phoenix on Saturday.
The Raptors improved to 14-3 in an NBA-high 17 home games. Toronto posted its 14th double-digit victory, matching Golden State and Portland for the league lead.
New York's Samuel Dalembert was thrown out in the third for elbowing Jonas Valanciunas in the face. After a review, the referees ruled it a flagrant-2 foul, which means an automatic ejection.
Ross got off to a quick start, scoring 10 of Toronto's first 15 points. Ross hit two 3-pointers and the Raptors went 5 for 11 from long range while building a 33-25 lead.
''They scored and they scored super-fast,'' Anthony said. ''They exploited a lot of things.''
New York trailed 58-51 at halftime, but Williams scored seven points in the third and Valanciunas had six as the Raptors took a 91-75 lead into the fourth.
Knicks: Amare Stoudemire (rest) and J.R. Smith (left heel) did not travel to Toronto. Stoudemire, who missed his second straight game, is expected to return Thursday against Washington. ... Dalembert's ejection left the Knicks with just nine available players.
Raptors: Landry Fields, who had eight stitches in his head after a fall in Friday's win at Detroit, was not available after failing his secondary concussion test. James Johnson started in his place and finished with 10 points. ... Toronto's 33 3-point attempts matched a season-high. They made 14, one shy of their season-best mark.
The Raptors scored 50 or more second-half points for the sixth consecutive game. They've outscored their opponents by 56 total points in that span, 324-268.
Ross provided the two highlight moments of the game with impressive dunks in each half. Ross took a pass from Valanciunas and cut through the lane for a one-handed jam in the first, then grabbed a long outlet pass from Lowry and absorbed a foul from Anthony as he finished a breakaway slam in the third. Ross was a rookie when he won the NBA's slam dunk competition at All-Star weekend in 2013.
Knicks: Host Wizards on Thursday.
Raptors: Visit Chicago on Monday.