The last-place Indians are in worse shape as losers of a season-high six straight and with Jason Kipnis on the disabled list entering Friday night's opener of a three-game home series against the White Sox.
Cleveland (11-17) completed an 0-6 trip in which it totaled 13 runs and batted .183 with Wednesday's 7-1 defeat to the Los Angeles Angels.
''It was a really tough trip. There's no way around it,'' manager Terry Francona said. ''Not a lot went right for us. But we have to put it behind us. We have to go fix it, and we'll do that.''
The Indians will have to try to fix it without Kipnis, who did not play Wednesday due to a strained abdominal muscle suffered the night before and was placed on the 15-day DL hours before this game.
Kipnis is hitting .234 with three homers and 12 RBIs. The Indians recalled infielder Jose Ramirez from Triple-A Columbus. Ramirez has a .319 average with four homers and 17 RBIs in 23 games for the Clippers.
Offense isn't a concern for Chicago (14-15), averaging 5.3 runs for one of baseball's best marks. The White Sox have been undone by a 4.81 ERA that is among the worst in the majors, with starters Felipe Paulino and Chris Sale currently on the DL.
"Well you'd like it to be better obviously but when you're dealing with injuries and things like that, at least you're still in the mix," manager Robin Ventura said. "Guys offensively had a good month and you just want to keep that up and play better."
Chicago has lost six straight at Cleveland, going 1-8 at Progressive Field last season. The White Sox lost their final 14 meetings with the Indians in 2013 before taking three of four at home April 10-13.
Danks gave up three runs in six innings for his first win in seven home decisions against the Indians. He's 3-1 with a 2.79 ERA in his last six starts at Cleveland.
The Indians are 3-8 against left-handed starters.
Francona may not want to start Michael Brantley since the outfielder is in a 1-for-17 slump and is 3 for 15 versus Danks. Carlos Santana is 2 for 15 against Danks and is one of baseball's worst hitters at .151.
Salazar yielded five runs in 3 2-3 innings the last time these teams met. That began a streak of three straight defeats in which the right-hander gave up five runs and failed to last past the fifth inning in each outing. That ended Sunday when he allowed one run in seven innings in a 4-1 loss at San Francisco.
Chicago's Alexei Ramirez is 6 for 7 against Salazar and went 7 for 16 with two homers and six RBIs in last month's series.