The A's can stretch their winning streak in the East Bay to seven games with an eighth straight home victory over the White Sox in Wednesday's series finale.
Oakland (25-15) opened this 10-game homestand totaling nine runs while losing three in a row to Seattle, but owns a 39-8 scoring advantage in winning the last six.
Brandon Moss homered twice and had five RBIs while four Oakland pitchers held Chicago (19-22) to four hits during Tuesday's 11-0 rout. The A's matched a season high with 17 hits while posting their third shutout on the homestand.
"When you're throwing a lot of strikes (hitters) can be aggressive with pitches in the zone,'' Moss said. ''That's what our guys were doing. Those kind of nights are fun four everybody."
Moss is batting .366 with half of his eight home runs and 12 RBIs in his last 10 contests.
Teammate John Jaso recorded his second consecutive three-hit game, and is 9 for 18 in his last four. He's 5 for 9 with two doubles in his last three against the White Sox.
A's starting pitchers have a 1.13 ERA during the six-game home winning streak, which followed a six-game slide there, and it's the club's longest such run of success since it won 11 in a row May 17-June 13.
''I think we feed off of each other," said Tuesday's winning pitcher Drew Pomeranz, who allowed three hits and struck out eight in five innings. "You want to keep it going. You don't want to be the guy that doesn't pitch well."
Oakland starter Tommy Milone (1-3, 4.54 ERA) was 0-3 with a 5.86 ERA in his first five starts and allowed a season-high six runs in a season-low four innings at Boston on May 3, but yielded two hits in eight innings of an 8-0 victory over Washington on Friday.
After teammate Dan Straily was sent down to the minors earlier that day, Milone felt some pressure to perform well.
''I think just the energy level, I felt lifted - just grab the ball, get on the mound and throw it,'' the left-hander said.
Milone's teammates know he's capable of more strong performances like his last.
''He was awesome," Moss said. ''We've definitely seen that all before from him."
Especially while allowing one run, seven hits and striking out 12 in 15 innings to go 1-0 in two starts versus Chicago, which has dropped four in a row since winning five of six.
Adam Dunn is 2 for 3 with a homer against Milone, and could be back in the lineup after he sat Tuesday. Dunn is 0 for 10 with five strikeouts in his last four games and 2 for 21 in his last eight contests.
Teammate Gordon Beckham batted .343 while hitting safely in eight straight games before he went 0 for 4 on Tuesday. He's 1 for 5 with two strikeouts versus Milone.
Chicago's Andre Rienzo (3-0, 4.56) will make his first appearance against the A's. The right-hander has allowed three runs in each of his last three starts and lasted 5 2-3 innings of a 9-3 victory over Arizona on Friday.