CHICAGO --- Alejandro De Aza had the game-winning two-run hit off Adam Warren in the Chicago White Sox's 6-5 12-inning win Wednesday over the New York Yankees.
Robinson Cano had homered off Dylan Axelrod (4-8) in the top of the inning to give New York a 5-4 lead but the White Sox rallied off Warren (1-2) to give the Yankees their fourth straight loss. With two outs Warren allowed Tyler Flowers to single off his glove, and then Alexei Ramirez to line a single to left before De Aza's drive.
Before that, Alex Rodriguez had a hit and Mariano Rivera blew his third save of the year.
Rodriguez, who on Wednesday officially appealed his 211-game suspension for his alleged involvement with the Biogenesis anti-aging clinic in Miami, was 1 for 5 with a strikeout and a walk as New York's third baseman and No. 3 hitter. In the 11th, Rodriguez had a chance to give New York the lead with Brett Gardner at third, but grounded out to end the inning and was then replaced in the field by Jayson Nix.
In his first three games of the season since being activated from the disabled list after hip surgery and then a quadriceps injury, Rodriguez has singled.
Rivera, who received a loud ovation before making his last appearance in Chicago, allowed a two-out double to Gordon Beckham then a game-tying single to pinch-hitter Adam Dunn to even the game at 4. Rivera got out of the inning by striking out Casper Wells.
He then pitched a scoreless 10th for his first two-inning appearance of the year but missed a chance for his 36th save.
CC Sabathia, who was 0-3 with a 10.07 ERA in his last four starts, pitched 7 1/3 innings and gave up five hits and three runs and was in line for his first win since beating Minnesota on July 3.
The New York offense, which had struggled mightily before Wednesday, showed some improvement. Alfonso Soriano and Eduardo Nunez homered for New York, which scored more than three runs for the first time since July 28.
Chicago, which swept consecutive series from New York for the first time since 1913, had starting pitcher Hector Santiago fail to pick up his first win since June 21. In 5 2/3 innings, Santiago gave up four runs and seven hits.
The White Sox scored two runs in the seventh to cut the New York lead to 3-2, with Paul Konerko doubling and then Beckham hitting into a fielder's choice when Cano threw to third to get Konerko.
After Sabathia was lifted in the eighth, David Robertson pitched a scoreless two-thirds of an inning, getting De Aza to tap back to the mound to strand Ramirez at second. Robertson also struck out Flowers, and White Sox pitching coach Don Cooper was ejected by home plate umpire Greg Gibson for arguing.
Robertson was protecting a lead the Yankees grabbed early.
Soriano gave the Yankees a 2-0 lead in the first inning on his second homer since getting traded back to New York on July 26. Brett Gardner led off the game with a bunt single, and Soriano drove a 1-1 Santiago pitch well into the left field bleachers.
Before Wednesday, Soriano had been hitting .211 (8-for-38) with four RBIs since changing teams.
New York took a 3-0 lead with two outs in the third when Vernon Wells' pop-up fell between White Sox first baseman Paul Konerko and right fielder Alex Rios, bringing in Soriano from second.
Nunez continued the Yankees' momentum in the fourth and gave them a 4-0 lead when he took a 2-2 Santiago pitch out to left field for his first homer of the season.
Gordon Beckham broke up Sabathia's shutout with one out in the fifth when he curved a towering drive around the left field foul pole to cut the New York lead to 4-1. Beckham was starting in the No. 5 spot in the batting order for the first time in his career.
NOTES: Yankees manager Joe Girardi said the team's attitude has been good, but the recent struggles have been a burden. "I think there's frustration, but they come prepared every day. They go to work every day," he said. ... Dayan Viciedo was Chicago's designated hitter, back in the lineup for the first time since jamming his left thumb during the first inning of Monday's game. ... A run-scoring wild pitch charged to White Sox LHP Chris Sale on Tuesday was changed to a passed ball for Josh Phegley. Thanks to the change, Sale has now five outings this year in which he didn't allow an earned run. ... After an off day, New York RHP Ivan Nova (5-4, 3.08 ERA) will start Friday in Yankee Stadium against Detroit Tigers RHP Rick Porcello (8-6, 4.28). Chicago is also off Thursday, then has a doubleheader Friday against the visiting Minnesota Twins. LHP John Danks (2-9, 4.52 ERA) will oppose Minnesota RHP Kyle Gibson (2-3, 6.69) in the first game. White Sox LHP Charlie Leesman will be called up to make his major league debut in the second game against RHP Liam Hendriks (0-1, 4-66).