This is Kentucky's sixth Elite Eight appearance in eight years under John Calipari.
North Carolina is a 2.5 point favorite and look to advance to their 20th Final Four appearance in school history.
These two teams played each other in Las Vegas in December with Kentucky coming away with a 103100 victory over the Tarheels.
Game time: 5:05 p.m. ET on March 26
Live stream: The game can be watched online with March Madness Live.