Miguel Cabrera never enjoyed much success against Chris Sale before finally going deep earlier this season.
These two will meet again after the reigning AL MVP enjoyed a weekend hitting two homers off another tough pitcher he had never gotten a hit against.
Cabrera looks to go four straight games with a homer for the second time this year when he matches up with Sale in Monday night's opener of a three-game set in Chicago.
Before 2013, Cabrera had a single in 11 at-bats against Sale (7-11, 2.77 ERA). He went 1 for 3 with a solo homer July 11 although the Chicago starter allowed three runs over 6 2-3 innings to earn a 6-3 victory.
Cabrera had been hitless in five at-bats including the postseason against Yankees closer Mariano Rivera prior to this year. That changed this weekend when he homered twice off the famed reliever, even though Detroit (69-47) lost two of three following its 12-game win streak.
''It doesn't happen that often with Rivera that you hit him twice like that and don't win either game,'' manager Jim Leyland said after Sunday's 5-4 defeat.
This will be Cabrera's first game in Chicago since he exited a 7-3 victory July 22 with a sore hip flexor muscle. He's 14 for 33 with four homers and 11 RBIs during a nine-game hitting streak.
The slugger last homered in four straight games May 19-23.
Detroit is 7-3 against Chicago (44-72), with Victor Martinez hitting .410 and Torii Hunter homering a team-high four times.
Martinez rested twice this weekend for Detroit and figures to be back in the lineup since he is 6 for 7 versus Sale this year. The Tigers, however, will be without catcher Alex Avila. He was placed on the seven-day concussion list after being hit in the mask by a foul ball Thursday, though he did play Saturday.
Sale is 1-1 with a 3.07 ERA and 19 strikeouts in two starts against the Tigers after going 0-3 with a 6.00 ERA in three in 2012.
The left-hander owns baseball's lowest run-support average at 2.53, although he got enough help to end a three-start losing streak last Tuesday after allowing one unearned run over 7 1-3 innings in a 3-2 victory over the Yankees.
Sale lowered his home ERA to 2.07 - the AL's second-best mark.
He'll be opposed by Doug Fister (10-5, 3.50), who is 4-0 with a 1.59 ERA in his last five outings. Fister's four-start win streak ended last Wednesday when he surrendered two runs over six innings with eight strikeouts in a 6-5, 14-inning win at Cleveland.
One of Fister's victories during his streak came Aug. 2, when he allowed one run in eight innings in beating the White Sox 2-1.
The right-hander has limited Paul Konerko to four hits in 23 at-bats and Gordon Beckham to four in 17. Adam Dunn is 6 for 10 with no homers off Fister.
Fister will get his first look at former Tigers outfielder Avisail Garcia.
The White Sox acquired the 22-year-old, who is 2 for 9 with his new club, from Detroit on July 30 in the three-team deal that saw Jake Peavy go to Boston.