Giants running back Ahmad Bradshaw will miss Sunday's game at the Atlanta Falcons with the sprained knee he suffered last week.
Bradshaw did not practice all week and was officially ruled out Friday.
"It would have been a reach for him to be ready," Giants head coach Tom Coughlin said. "With someone like that, his constitution, you have to give him every benefit of the doubt. I'm sure he'd be disappointed right now. He thinks come game day it's all going to straighten out for him. In this case, it's, medically, really the only wise move."
Rookie David Wilson will start in Bradshaw's place, and veterans Kregg Lumpkin and Ryan Torain, signed two weeks ago, are also likely to be active.
"They've worked hard; they've worked very hard at it since they've been here," Coughlin said. "They have been in the classroom since they got here to catch up and they've done a pretty good job at it. They've been on teams, so they know what to expect. Hopefully, if we can categorize how we use them, and their knowledge in that area is sufficient, they'll do fine.
Cornerback Prince Amukamara (hamstring) and safety Kenny Phillips (knee) have also been ruled out, as was backup safety Tyler Sash.
Linebacker Michael Boley, who experienced back pain Wednesday, is expected to be fine to face the Falcons. Wide receiver Hakeem Nicks (knee) and defensive end Jason Pierre-Paul (back) will also play.
"I feel real good actually right now," Nicks said. "This week... I had a good practice today, yesterday as well. The legs are feeling pretty good, so I'm looking forward to playing."