Vancouver heads to San Jose on Sunday in a battle of teams eliminated from postseason contention.
The Earthquakes (8-11-13) have lost three of their last four MLS matches, but did beat Vancouver 2-1 in mid-August in the teams' only other meeting this season. Quincy Amarikwa and Simon Dawkins had goals for San Jose against Vancouver.
A win over the Whitecaps on Saturday would give San Jose State its first season sweep over Vancouver since 2011.
The Whitecaps (9-15-8) have won only once in its last six MLS matches, but goalkeeper David Ousted expects a strong effort from his team.
"You might say that we have nothing to play for," Ousted said on Vancouver's team website. "I don't view it that way. Not at all.
We've got our jobs to play for, we've got the fans to play for, and we've got ourselves as a team.
"I don't want to go out with a whimper and tuck my tail between my legs. I want to go and win. And that has to be the mentality."
The Whitecaps will be shorthanded, with midfielder Pedro Morales suspended after receiving a red card in a 2-1 loss to the Seattle Sounders on Oct. 2.
Morales leads Vancouver with eight goals and is second on the team with six assists. Midfielder Christian Bolanos leads the team with seven assists.
Striker Bilas Perez also is suspended for the match, leaving Vancouver coach Carl Robinson with some decisions to make. His replacement options are limited, though, with a handful of younger players with the WFC2 for Saturday's USL Western Conference Final.
San Jose captain Chris Wondolowski has 10 career goals against Vancouver, the most any other player in MLS. He has helped the Earthquakes keep Vancouver winless (0-2-5) at Avaya Stadium.
Wondolowski has 12 goals this season to lead San Jose.
The Whitecaps host the Portland Timbers on Oct. 23 to wrap up the regular season. San Jose closes out the regular season on the road at Kansas City on Oct. 23.