BOSTON -- The Kansas City Royals snapped the Boston Red Sox's seven-game winning streak with a 4-2 victory in the first game of the day-night doubleheader on Sunday at Fenway Park.
Ervin Santana picked up the win, improving to 2-1. He went seven innings, giving up two runs and six hits with no walks and seven strikeouts.
After a leadoff single by Will Middlebrooks in the second inning, Santana retired 17 of the final 18 batters he faced. David Ortiz had Boston's only hit in that stretch with a sixth-inning double.
Ryan Dempster took the loss, falling to 0-2. He went seven innings, giving up four runs and six hits, including a home run, and three walks with eight strikeouts.
Kansas City scored first on Alcides Escobar's first-inning home run, his second homer of the season.
Boston went ahead in the bottom of the first when Daniel Nava, Dustin Pedroia and Ortiz hit consecutive one-out singles and Mike Napoli's groundout drove in a run.
But the Royals responded with three runs in the fourth. Billy Butler and Eric Hosmer opened the inning with back-to-back singles. Butler scored on Lorenzo Cain's double. After Dempster struck out Mike Moustakas and Jeff Francoeur, Salvador's Perez single to center scored Hosmer and Cain, giving the Royals a 4-2 lead.
Greg Holland pitched a perfect ninth for his fourth save.
NOTES: With his second-inning single, Jacoby Ellsbury extended his hitting streak to 10 games. ... With his first-inning single, Pedroia extended a streak of reaching base safely to all 17 games this season and 27 straight going back to Sept. 21, 2012. He is the first Red Sox player to reach base in the team's first 17 games of a season since Manny Ramirez did it in the first 23 games in 2001. ... Red Sox right fielder Shane Victorino left Saturday's game with lower back tightness and was not available for the opener on Sunday. ... With a fourth-inning RBI double, Cain extended his hitting streak to five games. He has hit safely in 10 of his past 11 games. He grounded out in his first at-bat snapping his streak of hits in seven consecutive at-bats. ... Dempster snapped Red Sox starting pitchers' streak of allowing just three or fewer runs at 16 games this season. He gave up four runs. ... Boston right-hander John Lackey, on the disabled list since April 7 with a biceps strain, is scheduled to make a rehab start for double-A Portland on Monday.