The New York Red Bulls ended their woes of more than a decade at Gillette Stadium earlier this year.
In contrast, the New England Revolution have yet to solve Red Bull Arena.
The Red Bulls are unbeaten in their last 10 home meetings with the Revolution, including a 4-0-1 mark at their current home entering Saturday night's critical matchup.
New York (5-6-10) had been 0-13-7 on the road in this series since 2002 before a 2-0 victory June 8 on goals by Eric Alexander and Peguy Luyindula.
The rematch gives New England (8-11-2) a chance to end an 0-4-6 road drought against New York, which has outscored the Revolution 11-4 in the five matchups at Red Bull Arena.
Red Bulls star Thierry Henry leads the league with 10 assists and has scored three goals in four home games against the Revolution. He doesn't play in New England since Gillette Stadium has artificial turf.
The Frenchman spearheads an attack that includes Bradley Wright-Phillips, who has a league-best 17 goals.
"That's something you get excited for when you're a defender, you want to defend and you like the challenge," Revolution defender Kevin Alston said. "What better challenge than New York. They've got a good team, they've got some great weapons, they've got Phillips up top doing well, scoring a lot of goals."
Both teams have to regroup quickly after matches Wednesday.
The Revolution ended the longest post-shootout era losing streak in club history at eight with a 3-0 home win over Colorado. Lee Nguyen and Kelyn Rowe had second-half goals and Charlie Davies impressed in his first home start.
"It feels great to finally get over the hump and get out of the rut," defender Andrew Farrell said. "I think offensively we were great. We've got players like Lee and Kelyn, and Charlie stepped up for us this past game, that when they're on, they're on."
The Red Bulls posted a 1-all road draw against Real Salt Lake. Henry scored his fifth goal while Wright-Phillips' five-match goal streak ended.
"It wasn't one of our best games, if I can say - but sometimes you have to get some result like that away from home, especially in a place like Salt Lake," Henry said.
New York has gone 1-1-4 in its last six games and has 25 points - one fewer than New England in the tightly packed Eastern Conference.
Coach Mike Petke said that he will be forced to make changes due to the short turnaround, especially since the Red Bulls played at altitude in Utah. New England coach Jay Heaps is also not sure who will be available for him.
"New York's in the same boat as we are," Heaps said.
Red Bulls defender Roy Miller played all 90 minutes Wednesday in his first match for the club since May 10. He was with Costa Rica for the World Cup, and had a leg injury when he came back but is healthy now.
Revolution defender Chris Tierney's status is uncertain after he missed the Colorado match with a knee injury. That's not the case for Red Bulls defender Jamison Olave, who's been suspended two games and fined an undisclosed sum by MLS for ''violent'' conduct toward an opponent in the RSL game.