Carl Pelini resigned as Florida Atlantic coach less than two years after taking the job because of what the school called illegal drug use.
FAU athletic director Pat Chun made the announcement on Wednesday afternoon. The resignation is effective immediately and Pelini will not be allowed to meet with the team.
Defensive coordinator Pete Rekstis also was involved in the drug use and and resigned along with Pelini. No other coaches or players were involved, Chun said. He called the behavior unacceptable.
Pelini did not attend an afternoon news conference but issued a statement.
"I apologize for exercising poor judgment," he said.
Offensive coordinator Brian Wright will become the interim coach. Linebackers coach Jevan DeWitt will fill Rekstis' spot as defensive coordinator.
The Owls, who suffered a 45-10 loss to Auburn last week, play host to Tulane on Saturday.
Pelini was in his second season at FAU. The Owls are 2-6 this year as a new member of Conference USA after posting a 3-9 record in 2012.
Pelini left his brother Bo Pelini's staff at Nebraska, where he served as defensive coordinator, to take the FAU job.