They hope to again get the better of Felix Doubront on Wednesday night and win their first series from Boston at Target Field since its inaugural season.
Chris Parmelee collected his first two RBIs of the season with a walkoff homer in Tuesday's 8-6 win, ending Boston's six-game winning streak at Target Field. Parmelee was 3 for 4, improving to 7 for 16 in four games since having his contract purchased from Triple-A Rochester on Friday.
"It's huge. It's one of those things that's a confidence builder," said Parmelee, who didn't make the team after spring training after playing 186 games with the big league club over the past three seasons. "In the long run, you've got to keep grinding."
Minnesota (18-19) also got a home run from Eduardo Nunez after totaling just three homers and 19 runs during a 3-4 stretch. The Twins had also hit .155 with runners in scoring position over the last seven games but were 3 for 9 on Tuesday.
Joe Mauer was 2 for 5 with an RBI and owns a .451 on-base percentage over his last 15 matchups with Boston.
The Red Sox (19-19) are still 9-4 at Target Field and Ortiz once again dominated the team he debuted with in 1997. Ortiz was 4 for 5 with two home runs - his 42nd career multihomer game and third against the Twins - with four RBIs. He owns a 1.106 OPS in 55 career matchups against Minnesota with 47 RBIs and has hit safely in 11 of his 12 games at Target Field with seven homers and 20 RBIs.
"Our meetings were, 'Don't let him beat us.' Well, that didn't work," Twins manager Ron Gardenhire said of Ortiz. "We'll have to change our meetings."
Boston's pitchers had posted quality starts in nine of 11 before Jake Peavy was tagged for six runs in 4 1-3 innings Tuesday. Doubront (1-3, 5.09 ERA) was initially scheduled to start Tuesday's series opener, but manager John Farrell chose to switch him with Peavy - a choice he had the luxury of making with Monday marking the first of three off days during an eight-day span.
Doubront was perhaps the most effective he's been this season his last time out, limiting Cincinnati to a run and five hits over 5 1-3 innings in a 4-3 victory on Tuesday. However, he's struggled in two games versus Minnesota, allowing 11 runs, 19 hits and six walks over 10 1-3 innings.
The left-hander is 7-3 with a 4.01 ERA in 15 career starts with six-plus days' rest.
Minnesota's Kevin Correia (1-4, 6.34) struggled in his most recent outing, throwing 4 1-3 innings and allowing four runs and eight hits in a 9-4 loss at Cleveland on Thursday. He also issued a season-high four walks.
Correia won his only previous start against Boston, yielding three runs and nine hits over 5 1-3 innings in a 5-3 victory on May 9 of last year at Fenway Park.
Shane Victorino, who was 3 for 5 Tuesday for his second three-hit performance in three games, is 8 for 17 off Correia. Ortiz is 0 for 3 against the right-hander.
The Twins haven't taken a series from the Red Sox at Target Field since their first season there in 2010.