The only baserunner allowed by San Francisco's Matt Cain in his last start was a single by the opposing pitcher.
He could again have trouble retiring his mound counterpart, as well as a couple of other hitters in the heart of the Philadelphia Phillies' batting order.
On Wednesday night in San Francisco, Cain takes the ball for the first time since tossing a one-hitter in a highly-anticipated matchup against Philadelphia's Cliff Lee.
Cain's first start for San Francisco (5-6) after signing a $127.5 million, six-year contract - a record for a right-hander - could have been labeled as a disappointment, as the two-time All-Star surrendered five runs, six hits and two walks against Arizona on April 8. His second start, though, was a thing of beauty.
Cain (1-0, 3.00 ERA) tossed a one-hitter - allowing only a two-out single in the sixth inning to Pittsburgh starting pitcher James McDonald - while striking out 11 in Friday's 5-0 victory. It was the third one-hitter, fifth shutout and 14th career complete game for Cain, who would have recorded the franchise's first perfect game had he been able to put away McDonald, an .079 career hitter.
The No. 9 spot in the batting order could again give Cain trouble, as Lee's 17 hits since the start of last season are tied for second-most among pitchers in the majors.
Lee (0-1, 3.46) singled in both of his at-bats Friday against the New York Mets, but ran into problems on the mound. He gave up four runs and five hits - including two homers - in seven innings of a 5-2 home loss. The left-hander, who has 26 career complete games and 11 shutouts, was 7-1 with a 0.97 ERA in his previous 11 starts dating to last season.
While Lee - who has never had an at-bat against Cain - could be a tough out, the Giants starter is likely more worried about No. 3 hitter Jimmy Rollins and cleanup man Hunter Pence.
Rollins is batting .412 with a home run, two doubles and three triples in 17 career at-bats against Cain, while Hunter Pence is 5 for 15 with a homer, double and triple.
Pence, whose role looms more vital for Philadelphia (5-6) with Ryan Howard and Chase Utley recovering from injuries, hit his second homer of the season in Tuesday's 4-2 loss that evened this series at a game apiece heading into the finale.
The Giants had a season-high 13 hits Tuesday, with Nate Schierholtz and Buster Posey each getting three, and Pablo Sandoval and Angel Pagan finishing with two apiece.
"We were able to scratch enough across to get the win," said Posey, who has increased his season average 125 points to .375 with two consecutive three-hit games.
Sandoval has hit safely in all 11 games for San Francisco, batting .341 with five doubles and nine RBIs, but is 1 for 8 lifetime against Lee.
Lee threw a seven-hitter in a 3-0 win in his lone start against the Giants last season, and has compiled a 0.82 ERA while winning his four regular season starts against them. He didn't fare nearly as well against San Francisco in the 2010 World Series with Texas, as he lost both his starts while posting a 6.94 ERA.
Cain split of pair of outings against the Phillies last season, allowing one earned run and seven hits over 15 innings but receiving just two runs of support.
He is 2-4 with a 3.56 lifetime ERA against Philadelphia including one postseason outing, yielding two runs or fewer five times but five runs or more in each of his other three starts.