Matt Cain is in danger of going winless in April for the second straight season.
It's been a little more than five years since the San Francisco right-hander earned a home victory against the San Diego Padres.
He'll try to end both droughts Tuesday night while looking to help the Giants bounce back from a series-opening defeat.
Cain (0-3, 4.35 ERA) went 0-2 with a 6.49 ERA in six April starts last season before posting his first victory May 5. He's been better this April, but needs to rebound after he allowed a season-high seven runs, 10 hits and two homers in six innings of a 12-10, 11-inning victory at Colorado on Wednesday.
Prior to that, he gave up a run, four hits and struck out eight in seven innings of a 2-1 loss at San Diego on April 18.
Cain is 0-3 with a 4.99 ERA in seven home starts against the Padres since beating them April 21, 2009. However, he has yielded three runs over 13 1-3 innings while San Francisco won his last two such outings.
The Giants' four-game winning streak ended with a 6-4 loss Monday. Catcher Rene Rivera hit a three-run homer and recorded his first five RBIs of the year for the Padres (13-14), who matched a season high for runs while winning for the third time in four games versus San Francisco (15-11).
"Sooner or later our hitting's going to come around," Rivera said. ''We needed this one. It's a good feeling. It's good for the team."
Rivera had two hits Monday, three fewer than he had coming into the contest.
"We needed a game like that from one of our guys,'' said Padres manager Bud Black, whose team has totaled 10 runs while winning two straight after scoring nine in the previous five contests.
''It's been a long time coming. We've had a hard time scoring runs in bunches.''
Rivera went 1 for 3 against Cain earlier this month.
Michael Morse had three hits with two RBIs and Buster Posey added a pair of hits as San Francisco lost for the second time in eight home contests.
Posey is 5 for 11 in three games after going 3 for 36 in his previous 12 contests.
He's 7 for 17 with two doubles and one home run against San Diego starter Eric Stults (1-2, 4.15), who looks for a third straight win versus San Francisco.
Stults allowed a fifth-inning homer to Morse and two other hits over six of a 3-1 win against the Giants on April 19.
"They're a pretty aggressive team and I had a hunch they would be swinging early," he said. "I was able to execute some pitches down in the zone. I was able to stay away from the heart of the plate."
The left-hander followed that up by holding Washington to two runs despite allowing 10 hits in 5 1-3 innings of a 4-3, 12-inning win on Thursday.
San Francisco slugger Pablo Sandoval is 1 for 11 versus San Diego this season, but 12 for 24 with three walks against Stults.
Posey has reached in half of his 20 plate appearances against Stults, with a homer and two doubles.