Bumgarner will try to help the Giants post a season-high fifth straight victory Monday night in the opener of a three-game set against the Padres.
San Francisco (15-10) hasn't dropped a series at home to San Diego (12-14) since losing two of three to close the 2010 season, although it captured the final game of that set to clinch the NL West over the Padres. The Giants have won 19 of their last 25 at home in this divisional rivalry.
Bumgarner (2-2, 3.14 ERA) is 3-0 with a 3.11 ERA in his last seven home outings against San Diego with 47 strikeouts over 46 1-3 innings.
The left-hander is seeking to avoid dropping three straight starts for the first time since Aug. 25-Sept. 5, 2012. He went the distance in Tuesday's 2-1 defeat at Colorado, lasting past the seventh inning for the first time.
Bumgarner won't be a pleasant sight to San Diego shortstop Everth Cabrera, who is hitless in 16 at-bats against him with six strikeouts. Another Padres hitter who has had little success versus the southpaw is Cameron Maybin, who is 5 for 21 with eight strikeouts.
Maybin's season debut Sunday was a success with two hits in a 4-2 victory at Washington that gave the Padres a four-game split. He ruptured his left biceps in spring training and missed the first 25 games.
"It's fun being back in the bigs, being out there with all these guys who I love playing with," Maybin said.
San Diego avoided a third straight loss and quickly recovered after committing three errors and managing three hits in Saturday's 4-0 defeat.
"What a difference 24 hours makes," manager Bud Black said. "I liked the way our guys bounced back. They put yesterday behind them and we won a ballgame on the road against a good team."
Black will give the ball to Tyson Ross (2-3, 3.16), who was born in Berkeley, raised in Oakland and takes matchups against San Francisco seriously. Ross earned his first win in four career starts versus the Giants on April 18 by striking out nine in eight scoreless innings of a 2-1 home victory.
"East Bay, man," Ross said afterward. "That was a lot of fun. I grew up an A's fan, so that rivalry's definitely there. The Giants were the rival at heart for me growing up."
The right-hander is 0-1 with a 3.75 ERA in two career starts at San Francisco. He has had trouble with Pablo Sandoval and Brandon Belt, who are each 4 for 9 off him.
The Padres took two of three from the Giants at home earlier this month. Only 14 runs were scored in that series.
San Francisco limited Cleveland to five runs in a weekend three-game sweep. Brandon Hicks hit a three-run homer in the bottom of the ninth inning in Sunday's 4-1 victory.
"You just want to try and keep your composure and stay calm because the crowd is yelling and everything," Hicks said. "You want to try and settle yourself down and stay within the moment."