Running back DuJuan Harris was placed on season-ending injured reserve by the Green Bay Packers.
Harris, who started both of the team's playoff games last season, aggravated a knee injury in last Friday's game against Seattle.
Rookie Eddie Lacy is now expected to open the season as the Packers' starting running back.
Offensive tackle Bryan Bulaga, wide receiver Kevin Dorsey and linebacker Jarvis Reed were also placed on IR.
Safety Sean Richardson, offensive tackles Derek Sherrod and JC Tretter and defensive end Jerel Worthy were placed on the reserve/physically unable to perform list and will miss at least the first six weeks of the regular season.