EUGENE, Ore. -- Known for its offense, Oregon saw its defense play the starring role Saturday.
The third-ranked Ducks held 22nd-ranked Arizona scoreless on seven trips inside Oregon's 30-yard line and got a couple defensive scores to win 49-0 Saturday night at Autzen Stadium.
Oregon took a 13-0 lead at halftime but did not have any of its usual big plays until De'Anthony Thomas returned a punt 38 yards midway through the third quarter.
Quarterback Marcus Mariota completed a 35-yard pass to Colt Lyerla on the next play, and then Colt Lyerla scored on a 1-yard run. Oregon made it 21-0 when punter Jackson Rice completed a pass to kicker Rob Beard for the two-point conversion.
Arizona's offense moved inside Oregon's 30-yard line for the sixth time following an interception by Jonathan McKnight that he returned to the Oregon 35-yard line, but once again the defense shut down the Wildcats. Arizona drove to the 16-yard line before quarterback Matt Scott was intercepted by Kiko Alonso on fourth down.
Two plays later, Mariota found freshman Bralon Addison for a 55-yard touchdown pass to give Oregon a 28-0 lead late in the third quarter.
The Ducks made it 35-0 when Ifo Ekpre-Olomu intercepted a Scott pass and returned it 54 yards for a touchdown in the opening minute of the fourth quarter.
Arizona drove deep into Oregon territory again in the fourth quarter but came up short on fourth-and-one at the 14-yard line.
Bryan Bennett added a 8-yard touchdown run for Oregon before Troy Hill capped the night with a 33-yard interception return for a touchdown.
Oregon scored first on an 88-yard drive, capped by Mariota's 17-yard touchdown pass to Daryle Hawkins with 5:42 left in the first quarter.
Beard stretched the lead to 10-0 on a 27-yard field goal with 5:55 left in the second quarter. Beard added a 41-yard field goal in the final minute of the half.
Arizona was left regretting five opportunities to score in Oregon territory that resulted in no points.
Oregon failed to convert on fourth-and-2 at its own 39-yard line on its first drive, and the Wildcats drove to Oregon's 4-yard line before lining up for a field goal. A bad snap kept the game scoreless, as Arizona was not able to attempt a kick.
Arizona recovered a fumble to end Oregon's second drive and got the ball at the Ducks' 11-yard line, but Scott was intercepted by Ekpre-Olomu two plays later. It was the first career interception for the sophomore cornerback.
Arizona had a first-and-goal at the 2-yard line on its third drive but was stopped on fourth down. Thomas fumbled on Oregon's next possession, and Arizona recovered at Oregon's 18-yard line, but John Bonano had a 31-yard field-goal attempt blocked.
Arizona reached Oregon's 29-yard line on its next drive before losing a fumble.
NOTES: Oregon starting wide receiver Josh Huff missed his second consecutive game due to a knee injury. ... Oregon's No. 3 ranking this week is its highest ever after the third week of the season.