Two goals from Javier Saviola were enough to send Olympiakos through to the Champions League knockout stage with a 3-1 win over nine-man Anderlecht on Tuesday.
The veteran striker scored on either side of a Sacha Kljestan goal to send the Greek champions into the last 16 at the expense of Benfica, despite missing a penalty earlier in the game.
Substitute Vladimir Weiss had a chance to all but seal qualification in the 72nd minute, but found Silvio Proto in inspired form as the goalkeeper kept out another spot kick. Fabrice N'Sakala then became the second Anderlecht player to be given his marching orders late on after Cheikhou Kouyate had been dismissed for a second yellow card.
Remarkably, a third penalty was awarded and Proto dismissed for his foul on Weiss, and substitute Alejandro Dominguez kept his cool against stand-in keeper Aleksandar Mitrovic to wrap up the win.
The result sends the Greek side through due to its superior head-to-head record against Benfica, which triumphed 2-1 against Group C winner Paris Saint-Germain.
Saviola and Michael Olaitan came into the Olympiakos starting XI as part of four changes to the side that beat Asteras Tripolis 2-0 in the Greek Super League on Saturday.
Anderlecht, meanwhile, made just one alteration from its 2-0 victory over Waasland-Beveren in the Belgian Pro League over the weekend, with Luka Milivojevic replacing the suspended Massimo Bruno.
Olympiakos applied the early pressure, but failed to take advantage of two free kicks from the edge of the penalty area. Saviola and David Fuster exchanged passes brilliantly in the 32nd minute to set up a chance for the Argentine, who glanced his effort agonizingly wide.
However, he made up for that miss less than a minute later, firing a low left-footed effort into the bottom right-hand corner of the net after receiving the ball from Fuster once again.
But Anderlecht leveled six minutes later with its first attack of the match. A counter from an Olympiakos corner culminated in Dennis Praet squaring the ball to Kljestan, who was left with a simple finish from 12 yards.
Olympiakos was awarded a penalty just four minutes into the second half, with Kouyate shown a second yellow card for his handball in the area. But the subsequent spot kick was poor, Proto getting down to his left to keep out Saviola's strike with relative ease.
Saviola went from villain to hero nine minutes later by acrobatically getting the final touch to a Fuster strike and diverting the ball beyond Proto to restore the hosts' lead.
Roberto had to be alert to deny Guillaume Gillet, before N'Sakala brought down Weiss in the area 18 minutes from time, handing the hosts a second penalty. But they failed to make the most of the chance once again as the Slovak was denied by Proto.
N'Sakala picked up his second yellow card in the closing stages and Proto followed him down the tunnel in stoppage time, with Dominguez completing the scoring from the spot.
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