Ohio State quarterback Braxton Miller is ruled out for Saturday's game against Florida A&M, according to ESPN.
Miller did not play last week against California because of a sprained left knee ligament but practiced this week.
Miller reportedly could have played but he and coach Urban Meyer mutually decided to have the junior quarterback sit out another game to rest.
Miller was injured two weeks ago against San Diego State.
Ohio State (3-0) is still heavily favored to beat Florida A&M (1-2). The Buckeyes open Big Ten play at home against No. 24 Wisconsin next week.
Kenny Guiton is expected to start at quarterback for the second consecutive game. He passed for 276 yards with four touchdowns and rushed for 92 yards against Cal last week.