No. 4 Ohio State laid another beating on an overmatched conference foe, and No. 24 Michigan State took control of the Big Ten's other division with a rout of Michigan.
The Buckeyes, coming off 49-point victory over Penn State, crushed Purdue 56-0 in West Lafayette, Ind. Ohio State has won 21 straight and has been far and away the Big Ten's most impressive team.
The Buckeyes appear to be cruising toward a Leaders Division title and their first Big Ten title game. They have a one-game lead over Wisconsin, a team they've already beaten, and have games left against Illinois, Indiana and Michigan.
Michigan State and the nation's No. 1 defense were even more impressive. The Spartans pummeled their rivals 29-6 in East Lansing, Mich., and have a game and a half lead in the Legends Division. Michigan State plays second-place Nebraska in two weeks. The Huskers kept pace by beating Northwestern 27-24 on a last-play touchdown pass.
No. 3 FLORIDA STATE 41, No. 7 MIAMI 14
TALLAHASSEE, Fla. (AP) -- Jameis Winston threw for 325 yards and Florida State rolled to another romp in a battle of ACC unbeatens.
Winston threw two interceptions in the first half after throwing four in the first seven games, but the Florida State defense shut out the Hurricanes (7-1, 3-1) in the second half after it was 21-14 at the break.
The Seminoles (8-0, 6-0) went on a 20-0 run after a skirmish broke out midway through the third quarter. The two teams were called for offsetting personal fouls and James Wilder Jr. scored on a 5-yard run on the next play. The rout was on from that point, not much different from Florida State's 51-14 win at Clemson last month.
Devonat Freeman ran for 81 yards and two touchdowns for Florida State against his hometown team.
Miami's Duke Johnson posted 97 yards on 23 carries, before leaving with a leg injury.
Winston threw one touchdown and Miami quarterback Stephen Morris threw for 192 yards with two touchdowns and two interceptions.
No. 4 OHIO STATE 56, PURDUE 0
WEST LAFAYETTE, Ind. (AP) - Doran Grant picked off Purdue's first pass, returning it for a touchdown, and Braxton Miller threw for 233 yards and four touchdowns as Ohio State extended the nation's longest winning streak to 21.
The Buckeyes (9-0, 5-0 Big Ten) have not lost in 22 months. Coach Urban Meyer also won his 22nd straight game, tying a personal best established at Florida. Ohio State scored the most points and produced the most lopsided scoring margin in the 56-game history of this series. Both topped the marks set in Ohio State's 49-0 victory in 2010.
Purdue (1-7, 0-4) lost its sixth in a row.
Gray's interception helped the Buckeyes take a 28-0 lead after one quarter, and they extended it to 42-0 at the half.
No. 8 AUBURN 35, ARKANSAS 17
FAYETTEVILLE, Ark. (AP) - Tre Mason rushed for 168 yards and four touchdowns as Auburn earned first-year coach Gus Malzahn a win in his return to Arkansas.
Mason scored on runs of 9, 4 and 5 and 12 yards as the Tigers (8-1, 4-1 Southeastern Conference) won their fifth in a row in Malzahn's first game in Fayetteville since leaving the Razorbacks as an assistant following the 2006 season.
Auburn's Nick Marshall, returning from a shoulder injury, accounted for 177 yards of total offense, including an 88-yard touchdown throw to Sammie Coates.
Jonathan Williams had 104 yards rushing and Alex Collins added 92 on the ground for Arkansas (3-6, 0-5), which has now lost six in a row. It's the longest losing streak for the Razorbacks since a seven-game stretch in 1990.
No. 9 CLEMSON 59, VIRGINIA 10
CHARLOTTESVILLE, Va. (AP) - Tajh Boyd threw three touchdown passes and ran for a score and Clemson broke the game open with three touchdowns in the last 4:18 of the first half.
The Hampton, Va., native became the Atlantic Coast Conference's career leader in touchdown-making with a 33-yard pass to Sammy Watkins to start the scoring for the Tigers (8-1, 6-1 ACC). It broke a tie at 112 TDs with North Carolina State's Philip Rivers. Boyd later added TD throws of 10 yards to Roderick McDowell and 96 yards to Watkins, and scored on a 1-yard run 13 seconds before halftime to make it 35-7.
Virginia (2-7, 0-5) lost its sixth in a row and for the 15th time in its last 19 games. It also suffered its second 59-10 loss at home this season, having lost by the same score against No. 2 Oregon in the second week of the season.
No. 10 MISSOURI 31, TENNESSEE 3
COLUMBIA, Mo. (AP) - Maty Mauk threw three touchdown passes and ran for another, leading No. 10 Missouri's dominant and resilient effort in a 31-3 victory over Tennessee Saturday night.
The Tigers (8-1, 4-1 SEC) responded smartly a week after squandering a 17-point cushion in the fourth quarter of a double-overtime loss to South Carolina. Andrew Baggett banged another chip-shot field goal attempt off the left goalpost, eerily similar to his game-ending misfire a week earlier, but instead of heartbreak they still took a 24-3 cushion into halftime.
Missouri forced three turnovers and committed none in Mauk's best game in three starts in place of injured James Franklin. Mauk had 114 yards on 13 carries, and threw touchdown passes to Dorial Green-Beckham, L'Damian Washington and Marcus Lucas in the first half. Franklin (shoulder sprain) warmed up before the game.
Tennessee (4-5, 1-4) is 0-4 on the road, all but one of them blowouts.
No. 12 TEXAS A&M 57, UTEP 7
COLLEGE STATION, Texas (AP) - Johnny Manziel threw four touchdown passes and ran for two more scores in less than three quarters to lead Texas A&M.
The Aggies trailed by five points early before scoring 55 straight to cruise to the victory against the overmatched Miners, losers of six straight.
Manziel threw touchdown passes of 44, 15, 17 and 26 yards and had TD runs of 10 and 49 yards before putting on his baseball cap with 7:39 left in the third quarter.
The Miners were done in by four turnovers, including two interceptions by A&M's Howard Matthews.
UTEP's Blaire Sullivan was making his first start with Jameill Showers, a transfer from A&M, out with a shoulder injury. Sullivan threw for 71 yards with three interceptions.
No. 14 SOUTH CAROLINA 34, MISSISSIPPI STATE 16
COLUMBIA, S.C. (AP) - Connor Shaw threw for four touchdowns, Mike Davis ran for 128 yards to move past 1,000 yards this season and South Carolina tied a school record with its 15th straight home victory.
Shaw matched his personal best for TD throws after missing two days of practice with a virus. Davis, the SEC's leading rusher, had his seventh game reaching the century mark and became the team's first 1,000-yard rusher since Marcus Lattimore gained 1,197 yards his freshman season three years ago.
South Carolina (7-2, 5-2 Southeastern Conference) won its seventh in row over the Bulldogs (4-4, 1-3) and tied the record for consecutive victories at Wlliams-Brice Stadium, equaling the mark set from 1978-80. The Gamecocks will get the chance to break the record in two weeks when they close league play at home against Florida.
No. 16 FRESNO ST. 41, NEVADA 23
FRESNO, Calif. (AP) - Derek Carr threw for 487 yards to break the Fresno State career passing record and lead the Bulldogs to an 8-0 start for the first time since 1989.
Carr threw three touchdown passes and ran for another to lead the way for the Bulldogs (5-0 Mountain West).
Josh Harper had 17 catches for 254 yards and two touchdowns and Josh Quezada ran for 115 yards to help Fresno State open with eight wins for the fifth time in school history and keep the Bulldogs in the running to make a BCS bowl game for the first time.
Kendall Brock scored on a 43-yard run on the opening possession for the Wolf Pack (3-6, 2-4), who have lost four straight games in a season for the first time since 2001. Cody Fajardo threw for 202 yards and two touchdowns.
No. 17 UCLA 45, COLORADO 23
PASADENA, Calif. (AP) - Brett Hundley threw two touchdown passes and rushed for two more scores, Devin Fuller scored three touchdowns, and UCLA shook off back-to-back losses.
Damien Thigpen also ran for a touchdown for the Bruins (6-2, 3-2 Pac-12), who rebounded from road defeats at Stanford and Oregon despite a sluggish start in their homecoming game.
Fuller caught a 76-yard TD pass for the Bruins' first score and added a rushing TD with 3:36 to play. Hundley passed for 273 yards and scored on runs of 11 and 1 yards while moving into third place on UCLA's career total yardage list.
Sefo Liufau passed for 247 yards for the Buffaloes (3-5, 0-5), who have lost 13 consecutive Pac-12 games.
No. 18 OKLAHOMA STATE 52, No. 15 TEXAS TECH 34
LUBBOCK, Texas (AP) - Clint Chelf threw for two touchdowns and a season-high 211 yards and ran for two more scores to lead Oklahoma State.
Desmond Roland ran for three touchdowns, a week after getting four for Oklahoma State (7-1, 4-1).
Chelf scored on a 67 yard quarterback draw, and was 18-for-34 passing with two interceptions.
The win keeps Oklahoma State in the Big 12 title hunt and makes the road for Texas Tech (7-2, 4-2) more difficult. The Red Raiders have lost two straight.
Cowboys returner Josh Stewart set up the last of Roland's touchdowns after returning a punt 46 yards in the third quarter.
Davis Webb was 45 for 71 for 425 yards and a touchdown, with two interceptions, for Texas Tech. Jace Amaro finished with 174 yards and a touchdown on 15 catches for the Red Raiders.
No. 21 NORTHERN ILLINOIS 63, MASSACHUSETTS 19
FOXBOROUGH, Mass. (AP) - Jordan Lynch ran for 119 yards and four touchdowns and threw for another in just over a half to help Northern Illinois stay unbeaten.
The Huskies (9-0, 5-0 Mid-American Conference) scored touchdowns on their first five possessions and six of their seven drives in the first half. Cameron Stingily rushed for 58 yards and a touchdown, and Tommylee Lewis also ran one in for Northern Illinois.
Lynch, who leads all active FBS players in rushing yards, also completed 10 of 14 passes for 160 yards and threw for at least one touchdown for the 22nd consecutive game. He played one series in the third quarter.
No. 22 WISCONSIN 28, IOWA 9
IOWA CITY, Iowa (AP) - James White ran for 132 yards and a pair of late touchdowns as Wisconsin won its third straight.
Joel Stave added two touchdown passes for the Badgers (6-2, 4-1 Big Ten), who are bowl eligible for the 12th year in a row.
Wisconsin's Pat Muldoon intercepted Iowa backup C.J. Beathard at the Hawkeyes 25 with 7:43 left, setting up an 11-yard TD run by White.
White added a 2-yard touchdown with 1:35 left for the Badgers, who won despite a season-low 62 yards rushing from Melvin Gordon.
Hawkeyes quarterback Jake Rudock had 109 yards passing for the Hawkeyes (5-4, 2-3) before leaving the game in the third quarter with an apparent left leg injury.
No. 24 MICHIGAN STATE 29, No. 23 MICHIGAN 6
EAST LANSING, Mich. (AP) - Shilique Calhoun, Ed Davis and the rest of Michigan State's defense battered rival Michigan, and the Spartans remained unbeaten in the Big Ten.
Michigan State (8-1, 5-0 Big Ten) has won five of the last six meetings with the Wolverines, and this was the Spartans' most lopsided win in the series since 1967. They held Michigan (6-2, 2-2) to minus-48 yards rushing, the worst output in the Ann Arbor program's history.
Connor Cook threw for a touchdown and ran for one, but this game belonged to Michigan State's defense, which solidified its spot among the nation's best with an overwhelming performance on a rainy afternoon at Spartan Stadium.
Calhoun and Davis each had 2 1/2 sacks.