The Blues captain missed his side's last three matches with a muscular problem picked up in training, having previously played every minute in the Premier League.
But Mourinho also revealed he will have to cope without David Luiz as he bids to extend Chelsea's lead over Arsenal and Manchester City at the top of the table.
"David Luiz is injured, but John Terry can play," the Chelsea boss told reporters. "[The injury to Luiz is] something in the muscle and he is feeling it. We need him, if possible, to be ready for Galatasaray. It's an injury in the abdominal area."
Everton, which sits sixth in the Premier League, has not claimed a league victory at Stamford Bridge since 1994.
However, Mourinho does not believe that Everton's poor record away to Chelsea will have any impact on the game.
"Everton are a very good team, playing well, getting good results, being in a position in the table that reflects their quality," the Portuguese added. "They are a good team; they defend well; they have experienced players like [Gareth] Barry and [Leon] Osman. It is a team with a good balance.
"I don't think stats play a part. It doesn't matter what happens in the past. We think we can beat them because we believe in ourselves and we work hard in the week to be in a good position for the match," he continued. "The table is there. You can look at the table and see how it is. We are top but can be second if Man City win the match they have in hand. If we win we keep the same position.
"If we don't beat Everton and lose points at home it's never good."