Michigan starting running back Fitzgerald Toussaint and backup defensive end Frank Clark will not play in Saturday's opener against defending national champion Alabama.
"The decision was not easy, but I feel it is in the best interest of this program and for these kids, and those always will be my priorities," Brady Hoke said in a release. "We have choices every day, and you have to be accountable to this program, your teammates, your family and the University of Michigan.
"These are our sons. These are real lives, and I think too often many people forget that. It's not always just about football, or a football decision. It's about teaching life lessons, and if this helps these kids or someone else make a right decision later, then we've won."
Sophomore running back Thomas Rawls is expected to start against Alabama. He played in four games as a freshman and had 13 carries for 79 yards.
The Wolverines suspended both players this summer after separate arrests. Toussaint was cited for drunk driving and Clark arrested for home invasion.
They returned to practice during fall camp and Michigan listed both on the depth chart before Hoke's ruling Friday.